Safer and more efficacious next-generation kinase inhibitor launches and expansion into therapy areas with no established standard of care to drive the Global Kinase Inhibitors in Autoimmune Diseases market growth during the forecasted period
LAS VEGAS, April 19, 2021 /PRNewswire/ -- DelveInsight's "Global Kinase Inhibitor in Autoimmune Diseases Market" report provides a thorough comprehension and the Global Kinase Inhibitor in Autoimmune Diseases market trends across the globe. The Global Kinase Inhibitor in Autoimmune Diseases market report also proffers an analysis of the current Global Kinase Inhibitor in Autoimmune Diseases treatment algorithm/practice, market drivers, market barriers, and unmet medical needs.
Pfizer, Eli Lilly, AbbVie, Gilead Sciences, Astellas Pharma, Japan Tobacco and Torii Pharmaceutical, Reistone Biopharma, Bristol Myers Squibb, Galapagos NV, Aclaris Therapeutics, Taiho Pharma, Oncostellae, Novartis Pharmaceuticals, Aclaris Therapeutics, Theravance Biopharma and Janssen (Johnson & Johnson), Kadmon Pharmaceuticals, Incyte Corporation, and others are the major players working in Global Kinase Inhibitor in Autoimmune Diseases Market regimen.
Monoclonal antibodies (biologics) have emerged a few decades ago and have become widely helpful. The most successful drug is Humira, which is currently the world's best-selling drug for the autoimmune diseases treatment.
A plethora of second-generation kinase inhibitors is currently in Phase II and III stage of development for indications such as Rheumatoid Arthritis, Psoriasis, Psoriatic Arthritis, Crohn's Disease, Ulcerative Colitis, primary Sjogren's syndrome, Atopic dermatitis, Systemic Lupus Erythematosus, Vitiligo, and others.
Besides the JAK inhibitors, compounds that target other kinase inhibitors such as SYK, SRC- family kinases, TYK2 or BTK inhibitors are expected to emerge as new therapy for autoimmune diseases hopes for TYK2 inhibition.
Global Kinase Inhibitor in Autoimmune Disorders market dynamics is anticipated to change in the future owing to the expected launch of emerging therapies such as SHR0302, Ruxolitinib, Branebrutinib, Ritlecitinib, Ritlecitinib/PF-06650833/ Tofacitinib, Abrocitinib, PF-06826647, Brepocitinib, SHR0302, Ruxolitinib, Branebrutinib, Deucravecitinib, Belumosudil, ATI-450, Remibrutinib, Izencitinib, and others during the forecasted period of 2020–2030.
Autoimmune and inflammatory diseases are common, and they can affect almost any organ system. Immunological disorders are diseases caused by a malfunctioning of the immune system. Historically, autoimmune and inflammatory diseases have been managed with medications that nonspecifically contain the immune system.
Monoclonal antibodies (biologics) impede the action of pathogenic cytokines that emerged two decades ago and have become broadly valuable for autoimmune and inflammatory diseases. Lately, agents that simultaneously hinder various pathogenic cytokines via inhibition of the downstream Janus kinase (JAK)-signal transducer and activator of transcription pathway have come up and are becoming increasingly imperative. These small-molecule inhibitors, collectively known as JAK inhibitors, are the US Food and Drug Administration sanctioned in a few autoimmune/inflammatory disorders and assessed in many others. First-generation jakinibs stop multiple JAKs and therefore hinder the actions of a tremendous variety of cytokines, and various pan-JAK inhibitors continue to be developed.
Xeljanz/Xeljanz XR is a JAK inhibitor that is formulated with the citrate salt of tofacitinib. JAKs are intracellular enzymes that transmit signals from cytokine or growth factor-receptor interactions on the cellular membrane to impact cellular processes of hematopoiesis and immune cell function. Within the signalling pathway, JAKs phosphorylate and activate signal transducers and activators of transcription (STATs), which modulate intracellular activity, including gene expression. Tofacitinib modulates the signalling pathway at the point of JAKs, preventing the phosphorylation and activation of STATs. It is approved for Rheumatoid Arthritis, Psoriatic Arthritis, Ulcerative Colitis, and Polyarticular course juvenile idiopathic arthritis (pcJIA).
Increased Research and Development: More than 400 diseases have been associated directly or indirectly with protein kinase. The success of kinase inhibitors in treating autoimmune diseases such as rheumatoid arthritis, psoriasis, and psoriatic arthritis has showcased their therapeutic potential. This success, coupled with a greater understanding of inflammatory signalling cascades, led to kinase inhibitors taking centre stage to pursue new anti–inflammatory agents for the treatment of immune–mediated diseases.
Safer next-generation alternatives: First-generation jakinibs block multiple JAKs and therefore inhibit the actions of a large variety of cytokines, and several pan-JAK inhibitors continue to be developed. The rationale for this is that nonselective JAK inhibitors have already been proven safe and that blockade of multiple JAKs might increase therapeutic efficacy. However, to minimise adverse effects, especially those arising from JAK2 inhibition, the generation of selective jakinibs could, in principle, maintain effectiveness and improve safety.
Convenient Administration: The main advantage of these tiny molecular weight kinase inhibitors is their oral administration versus the subcutaneous or intravenous administration of the monoclonal antibodies. This administration route facilitates adherence and increases patients' willingness to receive the treatment, and could reduce costs concerning the existing drugs. In addition, alternative routes, such as topical, for various dermatological indications and topical ophthalmic preparations, are being evaluated in the clinical setting.
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