AL Amyloidosis Market to Showcase Growth at a CAGR of 7.24% by 2032 | DelveInsight

The AL amyloidosis market is expected to show positive growth owing to the factors such as increased incidence and the anticipated launch of novel therapies during the forecast period (2019–2032).

LAS VEGAS, Oct. 3, 2022 /PRNewswire/ -- DelveInsight's AL Amyloidosis Market Insights report includes a comprehensive understanding of current treatment practices, AL amyloidosis emerging drugs, market share of individual therapies, and current and forecasted market size from 2019 to 2032, segmented into 7MM [the United States, the EU5 (the United Kingdom, Italy, Spain, France, and Germany), Japan].

Key Takeaways from the AL Amyloidosis Market Report

• As per DelveInsight analysis, the AL amyloidosis market size in the 7MM was approximately USD 920 million in 2021.
• As per the estimates, the total AL amyloidosis incident cases in the 7MM were approximately 8.6K in 2021. 
• Globally, leading AL amyloidosis companies such as Merck & Co, Janssen Pharmaceutical, Caelum Biosciences, Oncopeptides AB, Bristol-Myers Squibb, Acrotech biopharma, Sanofi, Astellas Pharma GmbH, Prothena, Alexion Pharmaceuticals, Celgene Corporation, and others are developing novel AL amyloidosis drugs that can be available in the AL amyloidosis market in the coming years.
• The promising AL amyloidosis therapies in the pipeline include Daratumumab, Birtamimab, CAEL-101, Melflufen, Elotuzumab, Evomela, Pomalidomide, and others.
• In recent decades, the current understanding of AL amyloidosis has improved, leading to growing awareness, improved management, and better outcomes.

Discover which therapies are expected to grab the major AL amyloidosis market share @AL Amyloidosis Market Report

AL Amyloidosis Overview

Amyloid light chain (AL) amyloidosis, often known as primary amyloidosis, is the most frequent kind of systemic amyloidosis. Historically, systemic light-chain (AL) amyloidosis was assumed to be an inescapable fatal disease. Prior to successful therapies for the underlying plasma cell dyscrasia, the AL amyloidosis prognosis was poor, with an estimated AL Amyloidosis life expectancy of 13 months and just 6 months for those with symptomatic cardiac involvement. Current AL amyloidosis staging approaches focus on indicators of myocardial cell damage and heart failure indicators, which are very sensitive to cardiac involvement in amyloidosis.

AL amyloidosis symptoms do not appear until the disease has advanced. The appearance of signs and symptoms is influenced by which organ is afflicted. Swelling of the ankles and legs, acute weariness and weakness, shortness of breath with minimum exercise, diarrhea, perhaps with blood, or constipation, numbness, tingling, or pain in the hands or feet, and others are the common AL amyloidosis symptoms.

AL Amyloidosis Epidemiology Segmentation

DelveInsight estimates that there were approximately 8.6K incident cases of AL amyloidosis in the 7MM in 2021.

Among the EU5 countries, Germany had the highest number of AL amyloidosis incident cases in 2021.

The AL amyloidosis market report proffers epidemiological analysis for the study period 2019–2032 in the 7MM segmented into:

• Total Incident Cases of AL Amyloidosis
• Gender-specific Cases of AL Amyloidosis
• Age-specific Cases of AL Amyloidosis

Download the report to understand which factors are driving AL amyloidosis epidemiology trends @AL Amyloidosis Epidemiological Insights

AL Amyloidosis Treatment Market 

The goal of AL amyloidosis treatment is to rapidly reduce the plasma cell clone to restore organ function by increasing amyloid reabsorption, hence improving heart function, patients' QOL, and survival. Chemotherapy (both standard and high dosage) coupled with autologous hematopoietic stem cell transplantation (ASCT) effectively reduces amyloid light chain development in appropriate people. Individuals who are ineligible for ASCT should be treated with melphalan, dexamethasone, and bortezomib-based regimens (BMDex). The National Comprehensive Cancer Network recommends high-dose melphalan followed by ASCT as one AL amyloidosis treatment option.

AL amyloidosis treatment is highly individualized, based on age, organ dysfunction, and regimen toxicity, and should be guided by hematologic and cardiac response indications. Almost two-thirds of patients benefit from alkylator-based chemotherapy. Novel agents are also in use, and trials to discover the best approach to utilize them are ongoing.

To know more about AL amyloidosis treatment options, visit @New Treatment for AL Amyloidosis 

AL Amyloidosis Pipeline Therapies and Key Companies

• Daratumumab: Janssen Pharmaceutical
• Birtamimab: Prothena
• CAEL-101: Alexion Pharmaceuticals
• Melflufen: Oncopeptides AB
• Elotuzumab: Bristol-Myers Squibb
• Evomela: Acrotech Biopharma
• Pomalidomide: Celgene Corporation

Learn more about the FDA-approved drugs for AL amyloidosis treatment @Drugs for AL Amyloidosis Treatment 

AL Amyloidosis Market Dynamics

The AL amyloidosis market dynamics are anticipated to change as a result of an increase in awareness and collaboration among key industry participants (commercialization of Darzalex Faspro by Genmab and Janssen Biotech, acquisition of Caelum Biosciences by AstraZeneca in 2021). Furthermore, The robust pipeline with a novel, first-in-class therapies for AL amyloidosis treatment is one of the primary factors propelling the AL amyloidosis market growth.

However, epidemiological data on AL amyloidosis is lacking, and retroactive analysis diminishes the data's legitimacy, restricting the expansion of the AL amyloidosis market. Furthermore, the diseases' complicated heterogeneity causes delays in diagnosis, resulting in severe disease (organ dysfunction - heart, kidney, liver), reducing AL amyloidosis survival rates, and serving as a barrier to the growth of the AL amyloidosis market. 

Moreover, due to poor patient recruitment and a lack of clearly defined new outcomes, AL amyloidosis clinical trials are challenging to conduct. The involvement of the cardiac and renal organs leads to a high treatment cost. In addition, the expected launches are likely to be more expensive than myeloma-based drugs, restricting the availability and affordability of AL amyloidosis treatments. Furthermore, in the age of daratumumab-based frontline treatment, the role of upfront ASCT in eligible patients must be clarified. As a result, the aforementioned factors impede the AL amyloidosis market growth.

Scope of the AL Amyloidosis Market Report

• Therapeutic Assessment: AL Amyloidosis current marketed and emerging therapies
• AL Amyloidosis Market Dynamics: AL Amyloidosis market drivers and barriers 
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Unmet Needs, KOL's views, Analyst's views, AL Amyloidosis Market Access and Reimbursement

Discover more about drugs for AL amyloidosis in development @AL Amyloidosis Clinical Trials

Table of Contents

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