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Acute Myeloid Leukemia Market to Exhibit Promising Growth at a 22% CAGR Fueled by Increasing Incidence and Imminent Launches of the Novel Therapies During the Study Period [2018-2030], States DelveInsight

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13 Jul, 2021, 16:30 GMT

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The Acute Myeloid Leukemia market has a promising outlook with less toxic emerging therapies in development for the elderly patients, which traditionally have been considered to have higher relapse rates

LAS VEGAS, July 13, 2021 /PRNewswire/ -- DelveInsight's "Acute Myeloid Leukemia (AML) Market" report provides a thorough comprehension of the Acute Myeloid Leukemia historical and forecasted epidemiology and the Acute Myeloid Leukemia market trends in the 7MM [the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan]. The Acute Myeloid Leukemia market report also proffers an analysis of the current Acute Myeloid Leukemia treatment algorithm/practice, market drivers, market barriers, and unmet medical needs. 

Some of the necessary takeaways from the Acute Myeloid Leukemia Market Research Report 

  • The Acute Myeloid Leukemia Market will increase because of an upsurge in research and development, enriched understanding of the disease, increased AML incidence, and imminent launches of the drugs. However, the AML market growth might be hindered due to the high cost of therapy, toxic therapies, limitations in designing clinical trials, and low survival rates. 
  • The AML treatment landscape has remained virtually unchanged for almost five decades. There have been recent approvals in frontline patient's intensive chemotherapy eligible patients such as VYXEOS (Jazz Pharmaceuticals), RYDAPT (Novartis), MYLOTARG (Pfizer), and ONUREG (BMS), and in ineligible patients Daurismo (Pfizer), TIBSOVO (Agios Pharma), and VENCLEXTA (Abbvie). Approvals relapsed/refractory and salvage settings include IDHIFA (BMS), XOSPATA (Astellas Pharma), and the recent approval of VANFLYTA (Daiichi Sankyo).
  • Despite the new therapies, there are several limitations associated with the current milieu of drugs. The high relapse rate in the high-risk population remains a significant concern. The overall survival in the elderly population remains relatively low.
  • Various new therapies are in development with a focus on mentioned limitations of the currently approved drugs. Some of the most prominent ones include ASTX 727 (Astex Pharmaceutical), CPI-613 (Rafael Pharmaceuticals), CX-01 (Chimerix), APL-106 (GlycoMimetics Incorporated), Quizartinib (Daiichi Sankyo), MLN-4924 (Millennium Pharmaceuticals), Iomab-B (Actinium Pharmaceuticals), SLS-001 (Sellas Life Sciences),  ARO-002 (Arog Pharmaceuticals), MGD-006 (MacroGenics),  FT-2102 (Forma Therapeutics), DF9-10917 (Delta-Fly Pharma) and SNDX-5613 (Syndax Pharmaceuticals).

For further information on Market Impact by Therapies, visit: Acute Myeloid Leukemia Drugs Market Analysis 

Acute Myeloid Leukemia (AML), also known as acute myelocytic leukemia, acute myelogenous leukemia, acute granulocytic leukemia, and acute non-lymphocytic leukemia, is a heterogeneous hematologic malignancy characterized by the clonal expansion of myeloid blasts in the peripheral blood, bone marrow, and/or other tissues. 

DelveInsight estimates that the total Acute Myeloid Leukemia incidence in the 7MM was estimated to be 42,301 cases in 2021. Also, the males appear to have a predisposition to AML, so a higher percentage of patients was observed in males than females. 

The Acute Myeloid Leukemia Market Analysis Report provides historical as well as forecasted epidemiological analysis segmented into: 

  • Total Acute Myeloid Leukemia Diagnosed Cases
  • Gender-specific Cases of Acute Myeloid Leukemia 
  • Age-specific Cases of Acute Myeloid Leukemia 
  • Genetic Mutation-specific Cases of Acute Myeloid Leukemia 

Get a complete epidemiological segmentation @ Acute Myeloid Leukemia Epidemiological Analysis 

Acute Myeloid Leukemia Treatment Market 

Treatment of most Acute Myeloid Leukemia patients typically consists of two chemotherapy (chemo) phases: remission induction (induction) and consolidation (postremission therapy). 

If the patients are not cured with the induction treatment, then a second, similar course of chemotherapy called reinduction can be tried. If this is also not helpful, treatment with other chemo drugs or more intensive chemo may be tried. A stem cell transplant may be an option for some patients. If the patients are still not cured, they may consider taking part in a clinical trial of newer treatments.

Although the Acute Myeloid Leukemia treatment arena is quite active and various trials are underway to treat patients, continuous efforts are further needed to develop novel drugs which would be more effective and less toxic. Along with that, support from the government and industry support are also necessary.

The AML market has a promising outlook with emerging therapies. Various new therapies are in development, and some of the most prominent ones include ASTX 727, CPI-613, CX-01, APL-106, Quizartinib, MLN-4924, Iomab-B, SLS-001, ARO-002, MGD-006, FT-2102, DF9-10917, and SNDX-5613.

Despite the new therapies, there are several limitations associated with the current milieu of drugs. The high relapse rate in the high-risk population remains a significant concern. The overall survival in the elderly population remains relatively low. The multitude of chromosomal and genetic abnormalities makes the AML treatment a challenging prospect as the heterogeneous nature of disease renders targeted agents vulnerable. The intensive chemotherapy treatments used for the indication have serious side effects that many older patients cannot tolerate. 

To conclude, the Acute Myeloid Leukemia Market will escalate since there has been advancing progress in understanding the genomic, proteomic, and metabolomic alterations of disease. The possibility of developing personalized therapy with improved clinical benefits is growing. Also, the incidence of Acute Myeloid Leukemia tends to increase over some time. Moreover, there has been a dramatic increase in much-needed research, including the approval of several products and ongoing clinical investigations for future therapies. The introduction of new drugs and increased access to therapies is expected to drive Acute Myeloid Leukemia market growth. The approval of novel therapies will serve a much larger patient pool and have demonstrated improved response in their target populations in several pivotal clinical trials, with some also demonstrated improved overall survival. 

Scope of the Acute Myeloid Leukemia Market Insight Report 

  • Geography Covered: The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. 
  • Study Period: 3-year historical and 10-year forecasted analysis (2018-2030).
  • Acute Myeloid Leukemia Markets Segmentation: By Geographies and By Acute Myeloid Leukemia Therapies (Historical and Forecasted, Current and Upcoming) 
  • Dominant Market Companies investigating its candidates for Acute Myeloid Leukemia: Pfizer, Bristol Myers Squibb, Agios Pharmaceuticals, Abbvie, Jazz Pharmaceuticals, Astellas Pharma, Daiichi Sankyo, AstraZeneca, Astex Pharmaceuticals, Inc, Chimerix, Takeda, Rafael Pharmaceuticals Inc., Delta-Fly Pharma, GlycoMimetics Incorporated, BerGenBio ASA, MacroGenics, Syndax Pharmaceuticals, Arog Pharmaceuticals, Forma Therapeutics, Sellas Life Sciences Group, Actinium Pharmaceuticals, Clear Creek Bio Inc., CellCentric Ltd., Biosight Ltd, Astex Pharmaceuticals, Inc., Curis, Inc., NexImmune Inc., Immunomedics, Inc, Sumitomo Dainippon Pharma Co., Ltd., Incyte Corporation, Aprea Therapeutics, Immunicum, DCPrime BV, GT Biopharma, Inc., Hanmi Pharmaceutical Company Limited, Cardiff Oncology, Bio-Path Holdings, Actinium Pharmaceuticals, Aptevo Therapeutics, Synimmune GmbH, GEMoaB Monoclonals, ImmunoGen, Inc., AGC Biologics S.p.A., Precigen, Inc., Novartis Pharmaceuticals, Xencor, Celgene, and several others. 
  • Analysis: Comparative and conjoint analysis of emerging therapies. 
  • Case Studies
  • KOL's Views
  • Analyst's View

Request for a Webex demo of the report @ Acute Myeloid Leukemia Therapeutics Market

Table of Contents 

1

Acute Myeloid Leukemia (AML) Key Insights

2

Acute Myeloid Leukemia Report Introduction

3

Acute Myeloid Leukemia Market Overview at a Glance 

4

Executive Summary of Acute Myeloid Leukemia

5

Acute Myeloid Leukemia Disease Background and Overview

6

Acute Myeloid Leukemia Epidemiology and Patient Population

6.1

The United States

6.2

EU5 Countries

6.2.1

Germany

6.2.2

France

6.2.3

Italy

6.2.4

Spain

6.2.5

The United Kingdom

6.3

Japan

7

Organizations contributing towards Acute Myeloid Leukemia

8

Case Reports of AML

9

Acute Myeloid Leukemia Patient Journey

10

Acute Myeloid Leukemia Marketed drugs

10.1

Daurismo (Glasdegib): Pfizer

10.2

IDHIFA (Enasidenib): Bristol Myers Squibb

10.3

TIBSOVO (Ivosidenib): Agios Pharmaceuticals

10.4

VENCLEXTA (Venetoclax): Abbvie

10.5

VYXEOS (Daunorubicin and Cytarabine): Jazz Pharmaceuticals

10.6

XOSPATA (Gilteritinib): Astellas Pharma

10.7

MYLOTARG (Gemtuzumab ozogamicin): Pfizer

10.8

RYDAPT (Midostaurin): Novartis Oncology

10.9

VANFLYTA (Quizartinib): Daiichi Sankyo

10.10

ONUREG (Azacitidine): Bristol Myers Squibb

11

Acute Myeloid Leukemia Emerging Therapies 

11.1

Inqovi (ASTX727 [Decitabine and cedazuridine]): AstraZeneca/Astex Pharmaceuticals, Inc.

11.2

Dociparstat sodium (DSTAT, CX-01): Chimerix

11.3

Pevonedistat (TAK-924, MLN4924): Takeda

11.4

Devimistat (CPI-613): Rafael Pharmaceuticals Inc.

11.5

Radgocitabine (DFP-10917): Delta-Fly Pharma

11.6

Uproleselan: GlycoMimetics Incorporated

11.7

Bemcentinib: BerGenBio ASA

11.8

Flotetuzumab (MGD006): MacroGenics

11.9

SNDX-5613: Syndax Pharmaceuticals

11.10

Crenolanib: Arog Pharmaceuticals

11.11

Olutasidenib (FT-2102): Forma Therapeutics

11.12

Galinpepimut-S: Sellas Life Sciences Group

11.13

Iomab-B: Actinium Pharmaceuticals

12

Other AML Promising Therapies

12.1

Brequinar: Clear Creek Bio Inc.

12.2

CCS1477: CellCentric Ltd.

12.3

Aspacytarabine (BST-236): Biosight Ltd.

12.4

Azacitidine and Cedazuridine (ASTX030): Astex Pharmaceuticals, Inc.

12.5

CA-4948: Curis, Inc.

12.6

NEXI-001: NexImmune Inc.

12.7

OPB-111077: Immunomedics, Inc.

12.8

Alvocidib: Sumitomo Dainippon Pharma Co., Ltd.

12.9

Ruxolitinib: Incyte Corporation

12.10

Eprenetapopt (APR-246): Aprea Therapeutics

12.11

DCP-001: Immunicum/DCPrime BV

12.12

GTB-3550 (OXS-3550): GT Biopharma, Inc.

12.13

HM43239: Hanmi Pharmaceutical Company Limited

12.14

Onvansertib (PCM-075): Cardiff Oncology

12.15

Prexigebersen (Liposomal Grb2 Antisense, BP1001): Bio-Path Holdings

12.16

Lintuzumab-Ac225 (Actimab-A/Ac-225): Actinium Pharmaceuticals

12.17

APVO436: Aptevo Therapeutics

12.18

FLYSYN: Synimmune GmbH

12.19

GEM333: GEMoaB Monoclonals

12.20

IMGN632: ImmunoGen, Inc.

12.21

MLM-CAR44.1 T-Cells (CD44v6): AGC Biologics S.p.A.

12.22

PRGN-3006: Precigen, Inc.

12.23

Sabatolimab (MBG453): Novartis Pharmaceuticals

12.24

Vibecotamab (XmAb14045): Xencor, Inc./Novartis

12.25

GSPT1 CELMoD (CC-90009): Celgene/Bristol Myers Squibb

13

Acute Myeloid Leukemia 7 Major Market Analysis

13.1

The United States Acute Myeloid Leukemia Market Size

13.2

EU-5 Acute Myeloid Leukemia Market Size

13.2.1

Germany Market Size

13.2.2

France Market Size

13.2.3

Italy Market Size

13.2.4

Spain Market Size

13.2.5

The United Kingdom Market Size

13.3

Japan Acute Myeloid Leukemia Market Size       

14

Acute Myeloid Leukemia Market Drivers

15

Acute Myeloid Leukemia Market Barriers

16

Acute Myeloid Leukemia SWOT Analysis

17

Acute Myeloid Leukemia Unmet Needs

18

Acute Myeloid Leukemia Market Access and Reimbursement

19

Acute Myeloid Leukemia KOL Views

20

Appendix

21

DelveInsight Capabilities

22

Disclaimer

23

About DelveInsight

Browse full report with detailed TOC with charts, figures, tables @ Acute Myeloid Leukemia Market Size 

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About DelveInsight

DelveInsight is a leading Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also provides Business Consulting Services with a credible market analysis that will help accelerate the business growth and overcome challenges with a practical approach. 

Contact Us:

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info@delveinsight.com   
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