Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

This Year's Crafoord Prize is Awarded for Fundamental Discoveries in Immune Regulation


News provided by

The Crafoord Prize

12 Jan, 2017, 05:24 GMT

Share this article

Share toX

Share this article

Share toX

STOCKHOLM, Sweden, Jan. 12, 2017 /PRNewswire/ -- Three immunology researchers share 2017's Crafoord Prize in Polyarthritis, for which the prize money is 6 million Swedish krona. The research being rewarded deals with the discovery of regulatory T cells, cells that can be regarded as our immune system's security guards. They put a brake on cells that are overzealous and attack the body's own tissue. There are hopes that their discoveries will lead the way to new, highly effective treatment methods for autoimmune diseases, such as rheumatoid arthritis, MS and type 1 diabetes.

The Royal Science Academy of Sciences has decided to award the 2017 Crafoord Prize in Polyarthritis to

Shimon Sakaguchi, Osaka University, Japan,

Fred Ramsdell, Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA

and

Alexander Rudensky, Memorial Sloan Kettering Cancer Center, New York, NY, USA,

"for their discoveries relating to regulatory T cells, which counteract harmful immune reactions in arthritis and other autoimmune diseases."

Autoimmune diseases arise when the body's immune system malfunctions, attacking normal tissue. Globally, these diseases cause great suffering and premature death for millions of people. Autoimmune diseases include multiple sclerosis (MS), type 1 diabetes and polyarthritis. The latter is a term used for rheumatic diseases in which multiple joints are affected.

There are great hopes that highly effective treatments for autoimmune diseases will be possible, based on new knowledge about the immune system that was gained over the last few decades. Three researchers are now being rewarded for their fundamental discoveries in the field: Shimon Sakaguchi, Fred Ramsdell, and Alexander Rudensky.

The Laureates' discoveries relate to regulatory T cells, which are the immune system's security guards. Their task is to keep an eye on other white blood cells that are overzealous in their task of defending the body from intruders and could harm things they should leave alone, such as healthy cells in joints, the pancreas or brain.

Even back in the 1960s, researchers were searching for suppressor cells in the immune system, but the research results were contradictory. Accordingly, over time, the consensus became that no such cells existed. Despite this, Shimon Sakaguchi persevered with the search and, after many years, he succeeded in identifying the cells that are now called regulatory T cells. Some years later, Fred Ramsdell approached the same area from a different direction; he isolated and identified the gene that is linked to severe autoimmune disease in a particular strain of mice. He also demonstrated that mutation in the same gene in humans, now known as FOXP3, causes a severe congenital disease called IPEX. Shortly afterwards, decisive findings were made, linking these two pieces of knowledge together. Alexander Rudensky, Shimon Sakaguchi and Fred Ramsdell each described how the FOXP3 gene is vital to a process that results in some T cells becoming security guards in the immune system. These are the regulatory T cells, which can prevent autoimmune reactions because they detect and suppress overzealous colleagues in the immune system.

A great number of clinical trials are now being conducted globally, with research teams testing various ways of using regulatory T cells to subdue the immune system's attacks that cause autoimmune diseases. The long-term vision is that of a breakthrough in the treatment of polyarthritis and other autoimmune syndromes, which could be treated more effectively than they are today.

Additional information, a video about this year's prize and illustrations for editorial use are available at:

http://kva.se/crafoordprize

www.crafoordprize.se

This year's Crafoord Prize

The Crafoord Prize is awarded as a partnership between the Royal Swedish Academy of Sciences and the Crafoord Foundation in Lund. The Royal Swedish Academy of Sciences is responsible for deciding upon the Crafoord Laureates.

The prize is awarded in one discipline each year, according to a set schedule for Mathematics and Astronomy, Geosciences, and Biosciences. The prize for Polyarthritis is awarded only when a special committee has demonstrated that scientific progress in this field has been such that an award is justified.

The prize amount is 6 million Swedish krona to be shared equally between the Laureates.

The award ceremony will be held at the Royal Swedish Academy of Sciences on 18 May 2017, in the presence of H.R.H. Crown Princess Victoria.

The Crafoord Days are 15-18 May 2017 in Stockholm and Lund. A detailed programme will be available at http://kva.se/events

Prize lecture: 16 May, Lund University.

Prize symposium: 17 May, Stockholm. Please register via http://kva.se/events

Prize ceremony: 18 May, Beijer Hall, Royal Swedish Academy of Sciences, Stockholm.

The Laureates

Shimon Sakaguchi, Professor at Osaka University, Japan. Discovered and documented the occurrence of regulatory T cells by systematically investigating cells that develop in the thymus of young mice, in a series of experiments from 1985 onwards. Born 1951.

www.ifrec.osaka-u.ac.jp/en/laboratory/experimentalimmunology/

Fred Ramsdell, Head of Research at Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. Identified the faulty gene in some mice and children that are born with IPEX, a severe autoimmune disease, in 2001. This gene, FOXP3, has proven to be vital in the development of regulatory T cells. Born 1961.

www.parkerici.org/about

Alexander Rudensky, Professor, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Knocked out the FOXP3 gene in mice in 2003, so they were unable to form regulatory T cells and thus suffered from severe autoimmune diseases. At about the same time, Sakaguchi and Ramsdell independently presented evidence that FOXP3 governs the formation of regulatory T cells and, at a stroke, a dynamic new field of research arose. Born 1956.

www.mskcc.org/research-areas/labs/alexander-rudensky

More information about the Crafoord Prize

http://kva.se/crafoordprize

www.crafoordprize.se

CONTACT:

Contact

Klas Kärre, Professor of Molecular Immunology,

Crafoord Prize Committee

Tel: +46 8 524 862 82

E-mail: klas.karre@ki.se      

Olle Kämpe, Professor of Clinical Endocrinology,

Crafoord Prize Committee

Tel: +46 70 815 1400

E-mail: olle.kampe@ki.se

Jessica Balksjö Nannini, Press Officer,

Royal Swedish Academy of Sciences

Tel: +46 70 673 9650

E-mail: jessica.balksjo@kva.se

This information was brought to you by Cision http://news.cision.com

http://news.cision.com/the-crafoord-prize/r/this-year-s-crafoord-prize-is-awarded-for-fundamental-discoveries-in-immune-regulation,c2164049

Related Links

http://www.crafoordprize.se

Modal title

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • Accessibility Statement
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.