The Hidden Genetic Threat Putting 1 in 5 at Cardiovascular Disease Risk: Global Experts Call for Action on Elevated Lipoprotein(a)

• Cardiovascular disease (CVD) kills nearly 18 million people each year, more than all cancers combined^1,2
• Elevated lipoprotein(a) or Lp(a), an inherited condition that raises CVD risk, affects 1 in 5 people worldwide but is rarely tested³
• New survey across Asia Pacific and Middle East shows 66% skip routine heart checks and nearly half are unaware of the genetic link to heart disease
• Experts urge audience to prioritize Lp(a) in cardiovascular strategies, bridging awareness gaps and driving equitable access to testing and care

SINGAPORE, Sept. 24, 2025 /PRNewswire/ -- Cardiovascular disease (CVD) kills nearly 18 million people every year, more than all cancers combined, yet one of its critical genetic risk factors remains largely invisible.^1,2 Elevated lipoprotein(a), or Lp(a), the "little a with big consequences," affects 1 in 5 people globally but is rarely tested and often overlooked in heart health strategies.^3,4

Ahead of World Heart Day (29 September), Global Heart Hub and Novartis convened international healthcare experts for the educational media webinar "Introducing the Little (a) with Big Consequences," to spotlight elevated Lp(a) as a critical, underrecognized inherited condition that independently increases risk of cardiovascular disease such as heart attack or stroke.^5,6

In the Asia Pacific and Middle East region, two in three individuals (66%) skip routine heart tests, while nearly half (45%) do not recognize genetics as a risk factor of heart disease, according to the results of a recent survey commissioned by Novartis. Awareness of Lp(a) is even lower, with just 22% of respondent reporting they had heard of a test for the biomarker, while only 7% had taken it.⁷

"Cardiovascular disease remains the world's leading cause of death, yet elevated Lp(a), a highly prevalent risk factor, is not even on most people's radar," said Neil Johnson, Executive Director of Global Heart Hub. "That has to change, and the media plays a vital role in putting this hidden risk factor into the global heart health conversation."

From Patients to Policy: A Global Call to Action

The session brought together leading voices from patient advocacy groups, medical science, and healthcare policy:

• Patient's Perspective: Ram Khandelwal, who survived a heart attack at age 33, shared how the experience inspired his advocacy work for India's first heart patient support group Heart Health India Foundation, and drove his efforts to raise the alarm on the dangers of elevated Lp(a) among its members.
• Scientific Insights: Prof. Gerald Watts, an expert in Cardio-Metabolic Medicine, University of Western Australia, explained the genetic science behind elevated Lp(a) and its impact on cardiovascular health.
• Policy Lens: Nicola Bedlington, Senior Policy Advisor/Project Lead, Lp(a) International Task Force, FH Europe Foundation (FHEF), urged policymakers to embed Lp(a) testing into national CVD guidelines to close critical care gaps. Supporting this, Prof. Zanfina Ademi, Professor, Health Economics, Monash University; Lp(a) International Task Force, FH Europe Foundation highlighted the cost-effectiveness of Lp(a) testing and its economic impact on health systems and society in the region.
• Cross-Regional Dialogue: Experts from Korea, India, Australia, and the Middle East (including Prof. Youngwoo Jang from Gachon University Gil Medical Center, Dr. A. Sreenivas Kumar from Apollo Hospitals India) addressed the challenges in diagnosing and managing elevated Lp(a), and the potential economic benefits of testing for it.

While awareness of elevated Lp(a) is dangerously low among Asia Pacific and Middle East survey participants, 58% of these respondents expressed interest in testing for genetic risk, representing a clear opportunity to empower individuals with knowledge that could save lives.⁷

The webinar concluded with a unified call to action to expand Lp(a) testing across the Asia Pacific and Middle East region, embed diagnosis and management of elevated Lp(a) into health systems with supportive policies.

"Every test taken could mean a life is saved, ensuring no heart is lost too soon," said Judith Love, President, Asia Pacific, Middle East & Africa at Novartis. "We must act now so that patients around the world are no longer left in the dark about this 'little (a) with big consequences,' but are instead empowered to take action on their own heart health."  

Notes to Editors

About Lp(a)
Lp(a) is a lipoprotein particle that is structurally similar to low-density lipoprotein (LDL) but distinguished by its apolipoprotein(a) component.⁸ This added protein makes Lp(a) particularly 'sticky', which can contribute to the build-up of plaque in the arteries.⁹

Elevated Lp(a) levels play a significant role in the development and progression of atherosclerotic plaque, which causes arterial blood vessels to narrow and harden, restricting the blood flow and oxygen supply to vital organs. It can also increase the risk of arterial blood clots forming. These blood clots can block the flow of blood, thus leading to cardiovascular events such as heart attacks, peripheral artery disease, or stroke.¹⁰

Lp(a) levels are approximately 90% genetically determined, are established mainly by the age of 5, and remain relatively consistent over a lifetime.^11,12 Consequently, lifestyle modifications such as diet and exercise have minimal impact on Lp(a) concentrations.

About Global Heart Hub
Global Heart Hub (GHH) is the first global non-profit organization established to provide a voice for those living with or affected by cardiovascular disease. GHH is an alliance of over 150 heart patient organizations, aiming to unite patient groups from around the world. GHH's aim is to unite patient groups from around the world and to raise awareness of heart disease and the challenges it presents in everyday life. GHH is a platform for heart patient organizations to share their views, learn from each other's best practice, unite on common advocacy goals, and share resources. GHH aims to increase awareness and understanding of the many heart conditions that exist, improve patient outcomes, enhance quality of life, and optimize longevity and healthy ageing.

About Novartis
Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people's lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach more than 250 million people worldwide.

Reimagine medicine with us: visit https://www.novartis.com.

References

[1] World Health Organization. (n.d.). Cardiovascular diseases. World Health Organization. Accessed Aug 22, 2025, from https://www.who.int/health-topics/cardiovascular-diseases#tab=tab_1
[2] World Health Organization. (2024, February 1). Global cancer burden growing, amidst mounting need for services. World Health Organization. Accessed Aug 22, 2025, from https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services
[3] Tsimikas S, Marcovina SM. J Am Coll Cardiol. 2022;80(9):934–946
[4] Kronenberg F, et al. The Brussels International Declaration on Lp(a) Testing and Management. Atherosclerosis. 2025. doi:10.1016/S0021-9150(25)00116-9
[5] Kronenberg F et al. Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement. Eur Heart J. 2022 Oct 14;43(39):3925-3946
[6] Vinci P et al. Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives. Int J Environ Res Public Health. 2023 Sep 6;20(18):6721
[7] Novartis-commissioned online survey, March 17–30, 2025; adults 21–75 in Australia, India, South Korea, Taiwan Region, Saudi Arabia, and the UAE (n=1,800; n=300/market); nationally representative by age and gender. Data on file.
[8] Schmidt K, Noureen A, Kronenberg F, Utermann G. Structure, function, and genetics of lipoprotein (a). J Lipid Res. 2016;57(8):1339-1359. doi:10.1194/jlr.R067314.
[9] Cox RA, Garcia-Palmieri MR. Cholesterol, triglycerides, and associated lipoproteins. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory
[10] American Heart Association. Lipoprotein (a) Meaning and How Does it Impact My Heart Health? [Internet]. American Heart Association; [cited 2025 May 26 2025]. Available from: https://www.heart.org/en/health-topics/cholesterol/genetic-conditions/lipoprotein-a-risks  
[11] Tsimikas S. A test in context: lipoprotein(a): diagnosis, prognosis, controversies, and emerging therapies. J Am Coll Cardiol. 2017;69(6):692-711.
[12] Wilson, D. P., Jacobson, T. A., Jones, P. H., Koschinsky, M. L., McNeal, C. J., Nordestgaard, B. G., & Orringer, C. E. (2019). Use of Lipoprotein(a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association. Journal of clinical lipidology, 13(3), 374–392.

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