Patient-Derived Xenograft/PDX Model Market worth US$0.66 billion by 2030 with 12.5% CAGR | MarketsandMarkets™
DELRAY BEACH, Fla., Nov. 21, 2025 /PRNewswire/ -- The global Patient-Derived Xenograft Model Market, valued at US$0.32 billion in 2024, stood at US$0.37 billion in 2025 and is projected to advance at a resilient CAGR of 12.5% from 2025 to 2030, culminating in a forecasted valuation of US$0.66 billion by the end of the period. The market is driven by the growing demand for personalized medicine, rising investments in cancer research, and continuous technological advancements in the development of PDX models. The increasing prevalence of cancer and the need for predictive, patient-relevant preclinical systems are driving the adoption of these systems across the pharmaceutical, biotechnology, and academic sectors, enabling more precise drug discovery, biomarker validation, and translational oncology research.
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By type, the PDX model market is segmented into mouse models and rat models. The mouse model segment is expected to witness the highest growth rate during the forecast period, driven by its genetic similarity to humans, well-established immune-deficient strains, and proven reliability in replicating human tumor biology. Mouse PDX models provide high tumor engraftment efficiency, reproducible tumor growth patterns, and compatibility with a wide range of cancer types, making them indispensable for preclinical drug evaluation and biomarker discovery. Their widespread use in oncology research, pharmacokinetic studies, and the development of personalized medicine further accelerates their demand. Ongoing advancements in humanized and immuno-oncology mouse models are also enhancing translational accuracy, positioning the mouse models segment as a critical driver of innovation and growth in the PDX model market.
By implantation method, the patient-derived xenograft (PDX) model market is categorized into subcutaneous implantation, orthotopic implantation, and others. The subcutaneous implantation segment accounted for the largest market share in 2024 and is expected to continue its dominance throughout the forecast period. This can be attributed to its technical ease, higher tumor engraftment success rate, cost-effectiveness, and reproducibility, making it a preferred choice among researchers and pharmaceutical companies for preclinical oncology studies. Subcutaneous implantation enables non-invasive tumor monitoring, facilitates rapid evaluation of drug efficacy, and supports high-throughput screening of anticancer compounds. Additionally, continuous advancements in animal model standardization and engraftment optimization have enhanced the consistency of results and their translational relevance. These factors collectively reinforce the adoption of subcutaneous implantation in drug discovery and development, solidifying its position as the leading implantation method in the PDX models market.
By geography, The Asia Pacific PDX model market is projected to witness the fastest growth during the forecast period, driven by the rising burden of cancer, expanding pharmaceutical and biotechnology research activities, and increasing emphasis on precision oncology. Strong government support for biomedical research, coupled with growing investments in translational and preclinical infrastructure, is further accelerating market development. Additionally, the availability of cost-effective research capabilities and skilled scientific expertise positions the Asia Pacific as a key hub for PDX-based drug discovery and personalized oncology research.
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Key players in the PDX model market include JSR Corporation (Japan), WuXi AppTec (China), The Jackson Laboratory (US), Charles River Laboratories (US), Taconic Biosciences, Inc. (US), Oncodesign Precision Medicine (France), Inotiv (US), Pharmatest Services (Finland), and Hera Biolabs (US), among others.
Charles River Laboratories (US):
Charles River offers one of the industry's largest fully characterized PDx portfolios, spanning major tumor histotypes and supported by searchable tumor-model databases and standardized study packages (including subcutaneous, orthotopic, and I/O readouts). CRL also validates humanized-immune PDx (HSC/PBMC) to run checkpoint/bispecific and cell-therapy studies, which is a key differentiator as sponsors shift to immuno-oncology combinations. Strategically, CRL has combined organic build-out with targeted M&A: the acquisition of Oncotest GmbH (2015) brought a deep European PDx franchise and know-how in orthotopic/PDOX and ex vivo assays, accelerating CRL's panel growth and clinical annotation depth. More recently, CRL partnered with Aitia to integrate AI "digital twins" with PDx workflows (LOGICA platform), aiming to improve candidate selection and responder enrichment—an example of CRL fusing wet-lab scale with computational prediction.
The Jackson Laboratory (US)
JAX operates a PDx Tumor Model Repository with hundreds of clinically annotated models available, either as contracted in vivo studies or distributed biospecimens. The resource is tightly integrated with the MMHCdb/PDx database, enabling selection by primary site, genotype, and prior dosing outcomes—a distinctive "data-first" entry point for sponsors. JAX's long leadership in NSG immunodeficient strains and humanized systems supports both conventional PDx efficacy and I/O-enabled studies. Beyond commercial services, JAX plays a visible role in community initiatives (e.g., PDxNet), contributing models, sequencing, and metadata standardization—features that are useful for sponsors who value open, comparable datasets and published methods.
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