Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multimedia
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multimedia
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

Panaxia Announces Positive Top-Line Results From Its Clinical Trial In Leading Medical Cannabis Products

This image opens in the lightbox

News provided by

Panaxia Pharmaceutical Industries

18 Dec, 2019, 13:05 GMT

Share this article

Share toX

Share this article

Share toX

Results demonstrate efficacy of absorption in the blood and safety of tablets, suppositories and inhaled cannabis extract

In addition, data show that Panaxia's sublingual tablets have a higher absorption rate and lower variance in comparison with the industry's Gold Standard 'Sativex' drug

"These clinical trial results are a significant achievement that showcase our R&D capabilities," says Dr. Dadi Segal, CEO of Panaxia Labs Israel Ltd. "What is common and obvious in every existing drug in the pharma world, is nothing less than revolutionary in the Israeli cannabis industry, which didn't start off in the pharma world, and as a result, the efficacy of absorption of cannabis products was never tested. Once they are approved, these products will set a higher therapeutic standard, enabling both the patient and the physician to know for certain how much of the substance has been absorbed into the bloodstream, the rate of absorption and the concentration in the blood. Moreover, we are thrilled about the preliminary data that emerged during the clinical trial, which indicate better characteristics in comparison to the industry's flagship drug. We intend to examine this data in a separate clinical trial, according to industry standards."

TEL AVIV, Dec. 18, 2019 /PRNewswire/ -- Panaxia Labs Israel Ltd, the largest manufacturer of medical cannabis products in Israel announced positive topline results in its clinical trial evaluating bioavailability and safety of use of a variety of innovative delivery methods of medical cannabis products developed by the Panaxia Group. This is the first clinical trial of its kind to take place in Israel, to the best of the company's knowledge, and one of the few performed in the world on medical cannabis-based products. An analysis of the results shows that the clinical trial successfully met its primary objectives.

The clinical trial commenced in January 2019 at the Wolfson Medical Center in Israel and included 12 healthy participants, according to a protocol approved by the Israel Ministry of Health (including the Medical Cannabis Unit) and by the Medical Center's Ethics Committee (Helsinki Committee). It was a controlled, double-blind, multi-disciplinary trial involving single-day treatment of each of the innovative forms of the product, including sublingual tablets in varying doses; suppositories and extracts for inhalation using an inhaler; as well as Axiban®, sublingual cannabis oil manufactured by the company and marketed by Rafa laboratories ; Sativex®, the Gold Standard flagship product of the worldwide cannabis industry, and the only product containing THC from a plant source (cannabis), which was approved for sale by the European Medicines Agency (EMA); and a placebo. The clinical trial included a 12-hour follow-up period for each participant and each form of administration, with a set amount of time between each segment.

The primary objectives of the clinical trial were to evaluate the safety and bioavailability of the active substances in the blood of each form of administration, as well as the pharmacokinetic profile of each of the products. By examining the bioavailability of the products (the concentration of the substance in the patient's blood, the rate of absorption in the bloodstream, and the fraction absorbed in the bloodstream of the total amount consumed), its pharmacokinetic efficacy was proven, and the main objective of the clinical trial was achieved. Moreover, regarding the products' safety of use, no serious adverse events (SAE) were reported.

In light of the positive results that were achieved, the company intends to move forward with procedures in order to receive regulatory approval for the various formats of its products in Israel and in a number of European countries. Upon regulatory approvals, the company will commence marketing these products in Israel and exporting them to a number of European countries.

In addition to achieving the objectives set out in the trial's protocol, the results analysis, comparing Panaxia's products with the industry's flagship Sativex products, indicate preliminary data  suggesting that according to the company, its products have the potential for a significant breakthrough in comparison with Sativex (some comparison results to Sativex lacking statistical significance due to small number of participants, all other results show statistical significance ).

It was found that (1) Sublingual tablets produced by Panaxia have a faster rate of absorption into the bloodstream compared to Sativex; (2) Sublingual tablets produced by Panaxia have a lower variance in the rate of absorption into the bloodstream from patient to patient compared to Sativex; (3) Cannabis extracts for inhalation produced by Panaxia have a higher rate of absorption compared to Sativex, as well as a lower rate of metabolism in the liver (first pass effect); and (4) Following the administration of Axiban oil, the level of analytes found in participants' plasma was similar to levels found after administration of Sativex.

In light of these preliminary data, the company is considering conducting a clinical trial to evaluate the efficacy and safety of Panaxia's products in comparison with Sativex, and include a larger number of participants, in order to achieve statistical significance. The company will update if and when it decides to conduct an additional clinical trial.

"These clinical trial results are a significant achievement, demonstrating our R&D capabilities and positions Panaxia as one of the leaders in the industry worldwide," says Dr. Dadi Segal, CEO of Panaxia. "As far as we know, Panaxia is the only Israeli medical cannabis company that has carried out such a comprehensive clinical trial to evaluate its products, and that has scientific proof of their bioavailability and safety. What is common and obvious in every existing drug in the pharma world, is nothing less than revolutionary in the Israeli cannabis industry, which didn't start off in the pharma world, and as a result the efficacy of cannabis products was never tested. The significance of this is that once they are approved, these products will set a higher therapeutic standard, enabling both the patient and the physician to know for certain how much of the substance was absorbed into the bloodstream, the rate of absorption and the concentration in the blood. This critical information will allow patients and their physicians to feel much more comfortable and assured that the product they are using has been checked, and that its effects on our bodies are known.

Dr. Segal added: "Moreover, we are also thrilled about the preliminary data emerging from the results, which indicate better characteristics in comparison to the industry's flagship drug. We intend to examine this data in a separate clinical trial, according to industry standards."

About Panaxia Israel
Panaxia Israel (www.panaxia.co.il) is part of the pharmaceutical group of the Segal family, operating for over four decades, and manufacturing over 600 different pharmaceutical products, which it distributes in over 30 countries. Panaxia was founded by Dr. Dadi Segal, Dr.Eran Goldberg and Assi Rotbart, LL.b, and constitutes the Group's cannabis division. In addition, the sister-division of North America manufactures over 60 pharmaceutical products based on medical cannabis, including sublingual tablets, oral tablets, oils, inhalers, and more, intended to treat conditions such as post-traumatic stress, cancer, chronic pains, epilepsy, anorexia, burns, and many other medical conditions. Panaxia employs around 90 employees and all clinical experiments are conducted by the company.

For further info: Email – robyn@panaxiapharmaceutical.com/ Tel (305) 933-4646

Logo - https://mma.prnewswire.com/media/822703/Panaxia_Pharmaceutical_Logo.jpg

Related Links

https://panaxia.co.il/

Modal title

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.