Niemann-Pick type C (NP-C) disease is a rare autosomal recessive lysosomal storage disorder with a variety of neurovisceral manifestations. It is caused by mutations in either NPC1 (more common) or NPC2 (less common) genes that lead to accumulation of cholesterol and glycosphingolipids in tissues. NP-C is divided according to the age at onset of symptoms, with an earlier onset of the disease predicting higher severity and poorer prognosis.
This report provides the current prevalent population for Niemann-Pick type C disease across 11 Major Markets (USA, Canada, France, Germany, Italy, Spain, UK, Japan, China, India, Brazil) split by gender and 5-year age cohort. Along with the current prevalence, the report also contains a disease overview of the risk factors, disease diagnosis and prognosis along with specific variations by geography and ethnicity.
Providing a value-added level of insight, subsets and some features of Niemann-Pick type C disease patients, as well as a wide variety of symptoms and co-morbidities have been quantified and presented alongside the overall prevalence figures. These sub-populations within the main disease are also included at a country level across the 10-year forecast snapshot.
Main symptoms and co-morbidities for Niemann-Pick type C disease include:
Dystonia and tremor
Cognitive and psychiatric problems
Key Topics Covered:
Cause of the Disease
Risk Factors & Prevention
Diagnosis of the Disease
Variation by Geography/Ethnicity
Disease Prognosis & Clinical Course
Key Comorbid Conditions / Features Associated With the Disease
Methodology for Quantification of Patient Numbers
Top-Line Prevalence for Niemann-Pick Type C Disease
Features of Niemann-Pick Type C Disease Patients
Comorbid Conditions of Niemann-Pick Type C Disease Patients