Renal cell cancer (RCC) is a tumor that originates in the renal cortex, the outer part of the kidney between the renal capsule and the renal medulla. Around 85% of all malignant kidney tumors are RCC, with other types including transitional cell carcinoma of the renal pelvis and Wilms' tumor (nephroblastoma).
The incidence of RCC is higher in those over the age of 60, suggesting that the aging population may play a significant role in current and future disease burden. It is estimated that in 2014 there were 100,290 diagnosed incident cases of RCC in the US, Japan, and five major EU markets (France, Germany, Italy, Spain, and the UK). Over the forecast period (2014-34), this is expected to increase to 137,970 cases by 2034, representing an absolute increase of 37.6%.
Overall, RCC incidence rates have been steadily increasing in both men and women in the US, Japan, and five major EU markets since the 1970s.