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Biotech Sector's Technological Advancements Winning Major Battles in the War on Cancer


News provided by

USA News Group

17 Jan, 2020, 14:00 GMT

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FN Media Group Presents USA News Group Commentary

LOS ANGELES, Jan. 17, 2020 /PRNewswire/ -- USA News Group – In the war against cancer, it appears that all hands are on deck, with contributions coming from across the biotech sector. As the 2020s begin, new approvals and promising data are encouraging the market to pay more attention to the developers of new treatments, including Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC), GlaxoSmithKline plc (NYSE:GSK), Aethlon Medical, Inc. (NASDAQ:AEMD), Clovis Oncology, Inc. (NASDAQ:CLVS), and Merck & Co., Inc. (NYSE:MRK).

Market researchers see big things to come from investment into the oncological war, with recent forecasts such as: the cancer gene therapy market surpassing $3.2 billion by 2026; the global breast cancer drug market offering a $40 billion opportunity; the noninvasive cancer diagnostics market hitting $195 billion by 2025; and the immunotherapy market estimated to reach $115 billion by 2023.

Key to the current optimism for drugs and therapies that are being developed, either from scratch or as enhancements.

PELAREOREP'S 1-2 COMBO PUNCH AGAINST CANCER

One thriving example an important enhancement therapy is pelareorep from Oncolytics Biotech Inc. (NASDAQ:ONCY) (TSX:ONC)—an immuno-oncolytic virus (OV) being combined some of the world's top selling anti-cancer drugs, including Keytruda ($7.2B in 2018 sales for Merck), Opdivo ($6.7B in 2018 sales for Bristol-Myers Squibb), Tecentriq ($766M in 2018 sales for Roche) and Bavencio ($75.5M in 2018 sales for Pfizer/Merck).

Recently Reuters published an analysis that revealed a record 89 therapies are currently undergoing human trials involving the pairing of treatments with antibodies with toxic agents to fight cancer—which Reuters calls "guided-missile" cancer drugs.

Like a guided missile, pelareorep selectively infects tumor cells, leading to the creation of inflamed tumors. These then engage the body's immune system to create of tumor reactive T cells.

This process is designed to enhance the likes of the market's best oncology drugs out there, as listed above. It does this by expanding existing T cell clones priming the immune system for checkpoint blockade. To date, the drug has synergized with all checkpoint inhibitor combinations tested.

So far, based on the final advice from the FDA following their EOP2 meeting, the company's been granted Special Protocol Assessment (SPA). It's been recommended that identification of biomarker should be done before Phase III. Confirmation of a single phase 3 study is required for approval.

Already across 13 clinical studies and a broad range of cancers, up to 96% of tumor samples tested positive for replicating pelareorep virus after intravenous delivery. To date, pelareorep is the only oncolytic virus with meaningful clinical data demonstrating intravenous delivery to tumor tissue.

To date, it's been used to treat 1,100 patients, over 900 of which were administered intravenously—So far, no maximum tolerated dose (MTD) has been reached.

Worldwide, Oncolytics Biotech Inc. (ONCY-ONC) has accumulated 398 patents issued, including 48 US and 21 Canadian, and more than 21 additional applications pending.

The reovirus issued patent claims cover compositions of matter comprising reovirus (through 2028 and extendable to 2033), and all pharmaceutical uses of it.

GUIDED MISSILE PARTNERSHIPS

Pharma giants, such as GlaxoSmithKline plc (NYSE:GSK), and Merck & Co., Inc. (NYSE:MRK) are throwing a lot of weight into these guided missile approaches—and there could be a lot more to come.

Between 2000 and 2018, US regulators only approved five antibody-drug conjugates (ADCs). In 2019, those same regulators approved three more, making it the largest one-year total ever. The tide is changing.

GlaxoSmithKline is currently testing its belantamab mafodotin against multiple myeloma. Most recently, the treatment's pivotal DREAMM-2 trial supported the drug's use for heavily-treated multiple myeloma.

Oncolytics Biotech Inc. (ONCY-ONC) has also recently highlighted pelareorep's unique ability to activate the immune system in late stage myeloma, with multiple myeloma data expected at ASCO 2020.

On top of the success of its top-selling Keytruda (which is being studied in combination with pelareorep), Merck has also added to the optimism for ADCs. The drug giant is ramping up its facilities in hopes that drugmakers will farm out complex ADC production. Merck expects the overall ADC market to grow by more than 20% in coming years.  

Clovis Oncology, Inc. (NASDAQ:CLVS) saw its stock soar after the FDA accepted its supplemental new drug application (sNDA) for its prostate cancer treatment Rubraca. The regulator granted priority review status for the drug, as recently presented data suggested Rubraca may play a meaningful role in the treatment of patients with BRCA1/2-mutant recurrent, metastatic castrate-resistant prostate cancer.

From a technological standpoint, Aethlon Medical, Inc. (NASDAQ:AEMD) and its Hemopurifier is still riding high from its own FDA approval of its Investigational Device Exemption (IDE) application back in October. The clinical-stage immunotherapeutic device removes exosomes and life-threatening viruses from the human circulatory system, which in turn can be used for the treatment of individuals with advanced or metastatic cancer.

For more information on the latest Biotech trends, please visit: https://usanewsgroup.com/2019/10/06/what-if-you-could-teach-your-body-to-fight-cancer/

Article Source:

USA News Group

http://usanewsgroup.com

info@usanewsgroup.com

Legal Disclaimer/Disclosure:

This piece is an advertorial and has been paid for. This document is not and should not be construed as an offer to sell or the solicitation of an offer to purchase or subscribe for any investment. No information in this Report should be construed as individualized investment advice. A licensed financial advisor should be consulted prior to making any investment decision. We make no guarantee, representation or warranty and accept no responsibility or liability as to its accuracy or completeness. Expressions of opinion are those of USA News Group only and are subject to change without notice. USA News Group assumes no warranty, liability or guarantee for the current relevance, correctness or completeness of any information provided within this Report and will not be held liable for the consequence of reliance upon any opinion or statement contained herein or any omission. Furthermore, we assume no liability for any direct or indirect loss or damage or, in particular, for lost profit, which you may incur as a result of the use and existence of the information, provided within this Report.

DISCLAIMER:  USA News Group is Source of all content listed above.  FN Media Group, LLC (FNM), is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with USA News Group or any company mentioned herein.  The commentary, views and opinions expressed in this release by USA News Group are solely those of USA News Group and are not shared by and do not reflect in any manner the views or opinions of FNM.  FNM is not liable for any investment decisions by its readers or subscribers.  FNM and its affiliated companies are a news dissemination and financial marketing solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security.  FNM was not compensated by any public company mentioned herein to disseminate this press release.

FNM HOLDS NO SHARES OF ANY COMPANY NAMED IN THIS RELEASE.

This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.

Media Contact Information:
FN Media Group, LLC
Media Contact e-mail:  
editor@financialnewsmedia.com 
U.S. Phone: +1(954)345-0611

Related Links

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