Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

Research Consortium led by Grünenthal Receives € 2 Million Grant from the European Fund for Regional Development and the State of North Rhine-Westphalia


News provided by

Grünenthal Group

16 Nov, 2017, 10:41 GMT

Share this article

Share toX

Share this article

Share toX

AACHEN, Germany, November 16, 2017 /PRNewswire/ --

- "LifeSciences.NRW" grant to support the discovery and development of new pain relief drugs 

- Grünenthal founded and leads the Consortium to which Taros Chemicals and the Research Centre Jülich belong 

Many patients who suffer strong or persistent pain receive inadequate relief from therapy. Improving pharmacotherapy and management for refractory pain is a so enormously complex problem that only concerted approaches which link together groups with different relevant expertise are likely to have success in discovering and developing novel and effective analgesics. Grünenthal, aiming at driving new solutions in pain, organized and leads such a partnership with three research groups from the Institute for Neurosciences and Medicine (INM) of the Research Centre Jülich, and with Taros Chemicals, a firm specialized in chemical design and synthesis. Together they designed an ambitious project which could pave the way to analgesic drugs with novel dual modes of action which target causes of refractory pain. This project is entitled "Development of PET-ligands to demonstrate the duality of the mechanisms of action of new analgesics" (Dual2PET).

LifeSciences.NRW is responsible for overseeing that European and regional development funds for the State of North Rhine-Westphalia are used to support this cooperative public-private partnership strategy with non-dilutive research grants. The Dual2PET research proposal was submitted to LifeSciences.NRW, and against strong competition from other North Rhine-Westphalian partnerships, won a research grant. The project will receive € 2 million over three years from the European Funds for Regional Development and the State of North Rhine-Westphalia (Reference number EFRE-0800988), and started on 1st July 2017.

Approximately 20% of all Europeans suffer from chronic, long-lasting or recurring pain, and 60% of these patients cannot be adequately treated with currently available medications[1]. This situation causes enormous suffering to both the patients and their families.

Improved therapies for chronic pain will require highly innovative approaches which preferentially allow more than one pathological mechanism - mechanisms which cause diseases - to be influenced beneficially and simultaneously. Drugs which have more than one mechanism of action interact with more than one pharmacological target ("multiple ligands"). However, identifying such ligands is extremely difficult, and their transfer from preclinical research to clinical practice has been unsuccessful. The unsolved problem is to prove that candidate multiple ligands actually modulate simultaneously their multiple targets in animals and humans.

One possibility to prove the interaction of a new ligand with its targets is to employ newly developed imaging techniques such as positron-emission tomography (PET). This technology is employed in nuclear medicine to investigate and quantitate biological processes in a non-invasive and repeatable manner. The Dual2PET Consortium led by Grünenthal aims to develop a unique method whereby it will become possible to demonstrate the interaction of a single drug with two specific targets.

A method which allows such promising multiple ligands to be designed and then tested whether the pharmacological properties can be proven, first in animals and then in humans (Translational Medicine), would represent an enormous improvement for pharmaceutical research and development. Complex clinical developments would only be initiated after demonstrating a reasonable chance that a candidate has the desired properties. The Dual2PET approach is a paradigm shift which could save costs lost due to inadequate efficacy of candidates in clinical trials, and enhance the success rates by excluding candidates which lack promise, and thus provide patients with improved therapies more quickly.

About the Consortium 

The scientific and technical challenges of this project are very complex, and can only be solved by an interdisciplinary team with extensive and complementary experience: Research at Grünenthal investigates pathological mechanisms which lead to pain in order to develop analgesics with improved properties. One focus is to employ innovative methods which promise an improved rate of translation from preclinical research into successful clinical practice, and so reduce the high attrition rate in clinical trials. The Dual2PET project will expand the research network and strengthen the science of Grünenthal's pain research.

Taros Chemicals is a small-to-medium sized enterprise (SME) with wide experience with organic and metallo-organic chemical syntheses. They use their state-of-the-art infrastructure and hardware to tackle complex synthesis and analysis techniques to apply a wide spectrum of computer-assisted drug design methods such as molecular modeling, virtual screening, adaptive structure-activity analyses and statistical prognoses.

The Research Centre Jülich involves itself in the Dual2PET project through three of its Institutes for Neurosciences and Medicine, "Molecular organization of the brain" (INM2), "Nuclear chemistry" (INM-5) and "Computational biomedicine" (INM-9/IAS-5).

They will investigate structural and functional changes in neurological and psychiatric diseases in order to improve early diagnosis and therapy. A central research focus will be the application of quantitative molecular imaging techniques such as positron-emissions tomography.

The consortium looks forward to the ground-breaking results from this pain project in the next years.

About the Leitmarktwettbewerb "LifeSciences.NRW" 

The State of North Rhine-Westphalia created the competitive granting body LifeSciences.NRW in 2015 in order to support the development of solutions to problems of health and welfare in the aging population. Consortia of academic institutions, SMEs and pharmaceutical companies in NRW were offered the opportunity to compete for financial support of innovative biomedical research and development projects provided by the European fund for regional development. The intention is to strengthen growth and employment in NRW, and increase its visibility as a leading location for the life sciences.

About Grünenthal 

The Grünenthal Group is an entrepreneurial, science-based pharmaceutical company specialized in pain, gout and inflammation. Our ambition is to deliver four to five new products to patients in diseases with high unmet medical need by 2022 and become a € 2 bn company. We are a fully integrated research & development company with a long track record of bringing innovative pain treatments and state-of-the-art technologies to patients. By sustainably investing in our R&D above the industrial average, we are strongly committed to innovation.

Grünenthal is an independent, family-owned company headquartered in Aachen, Germany. We are present in 32 countries with affiliates in Europe, Latin America and the US. Our products are sold in more than 155 countries and approx. 5,500 employees are working for the Grünenthal Group worldwide. In 2016, Grünenthal achieved revenues of approx. € 1.4 bn.

More information: www.grunenthal.com

Follow us on LinkedIn "Grunenthal Group".

About Taros Chemicals 

Taros Chemicals, a privately owned CRO / CMO has been serving the needs of pharmaceutical, chemical and biotech companies since 1999. More than 10.000 synthesis, research and process chemistry projects have successfully been delivered to the global customer base. Taros' scientists combine more than 140 years industrial organic chemistry experience and over 60 years of active drug discovery experience. They have expertise in major therapeutic areas and in all small molecule target classes. Taros Chemical covers the full range of organometallic chemistry research and production from lab scale size to several hundred Kgs supply per year. This includes screening/focused library design and production, computer aided drug design, medicinal chemistry services engaged in hit finding, hit to lead and lead optimization works as well as material science and specialty chemistry driven R&D services including research, design, route scouting, process development and non-GMP production & delivery of up to 1.000kg / year of such performance chemicals. Taros Chemicals have developed TarosGate®, a unique software suite putting cost, time and chemistry information at a Project Leader's finger tips - 24h/7 from anywhere in the world. TarosGate® is a major cornerstone of the 196 Mio. Euro European Lead Factory (ELF) drug discovery platform. Taros Chemicals is leading ELF's chemistry activities since 2013. www.tarosdiscovery.com

About Research Centre Jülich
The increasing level of digitization both requires and enables innovations in the areas of high-performance computing, scientific simulation, and big data, as well as on future technologies such as quantum computing and neuromorphic computing. Jülich scientists also explore the coding of information in molecular-biological structures such as proteins and neural information processing in the human brain. Understanding the complex processes of the brain is crucial to a more effective diagnosis and treatment of brain diseases.

Media Contact:
Steffen Fritzsche
Head Corporate Communications
Tel: +49-241-569-1335
steffen.fritzsche@grunenthal.com


References
[1] van Hecke O, Torrance N, Smith BH. Chronic pain epidemiology and its clinical relevance. Br J Anaesth. 2013; 111(1):13-8.

Modal title

Also from this source

Grünenthal announces acquisition of the rights to Cialis® from Lilly in Mexico, Brazil & Colombia

Grünenthal today announced the acquisition of the commercial rights to Cialis® (tadalafil) in Mexico, Brazil and Colombia from Eli Lilly and Company. ...

Apotex licenses exclusive Canadian rights to Qutenza® from Grünenthal

Grünenthal, a global leader in pain management and related diseases, and Apotex Inc. ("Apotex"), the largest Canadian-based pharmaceutical company,...

More Releases From This Source

Explore

Health Care & Hospitals

Health Care & Hospitals

Medical Pharmaceuticals

Medical Pharmaceuticals

Pharmaceuticals

Pharmaceuticals

New Products & Services

New Products & Services

News Releases in Similar Topics

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • Accessibility Statement
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.