Published recently in European Endocrinology, the peer-reviewed, PubMed-indexed journal from touchENDOCRINOLOGY, Baptist Gallwitz discusses the recently published real-world data on the cardiovascular (CV) benefits associates with the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in type 2 diabetes (T2D). T2D is associated with numerous comorbidities that significantly reduce quality of life, increase mortality and complicate treatment decisions. In a recent cardiovascular outcomes trial, Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME), the sodium-glucose SGLT2 inhibitor empagliflozin was shown to reduce CV mortality and heart failure in high-risk patients with T2D with a previous CV event or with established CV disease (CVD). Recently published data from the Canagliflozin Cardiovascular Assessment Study (CANVAS-PROGRAM) study suggested that the cardiovascular benefits of empagliflozin are also seen with the SGLT2-inhibitor canagliflozin, indicating a class effect of SGLT2 inhibitors. Evidence for a class effect has also been shown by meta-analyses and real-world studies, including the Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors (CVD-REAL) and The Health Improvement Network (THIN) databases. These findings also suggest the results of EMPA-REG OUTCOME can be applied to patients with T2D with a broader CV risk profile, including people at low risk of CVD.
The full peer-reviewed, open-access article is available here:
Disclosure: Baptist Gallwitz discloses the following: Board Member/Advisory Panel for Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly & Co., Janssen, Merck Sharp & Dohme, Mylan, Novartis, Novo Nordisk. Speaker honoraria: Amgen, Abbott, AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Eli Lilly & Co., Merck Sharp & Dohme, Novo Nordisk, Sanofi. The publication of this article was supported by AstraZeneca. The views and opinions expressed are those of the author and do not necessarily reflect those of AstraZeneca.
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