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Marizyme Announces the Use of DuraGraft® as the Standard-of-Care in Patients Undergoing Coronary Artery Bypass Surgery (CABG) at Vienna Heart Center North Floridsdorf


News provided by

Marizyme, Inc.

11 Jan, 2021, 10:33 GMT

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DuraGraft is a one-time intraoperative treatment used during vascular surgery to reduce the incidence of complications associated with graft failure

JUPITER, Fla., Jan. 11, 2021 /PRNewswire/ -- Marizyme, Inc. (OTCQB: MRZM), a global biotechnology company developing products to reduce the burden of ischemia-reperfusion injury in tissue grafting, organ transplant, and other surgical indications, today announced as of August 2020 the Vienna Heart Center North Floridsdorf of Vienna, Austria was the first clinic worldwide to use the company's flagship product, DuraGraft® as the standard-of-care for flushing and storage of the saphenous vein grafts from harvesting through grafting in Coronary Artery Bypass Grafting (CABG) patients.

Vienna Heart Center North Floridsdorf, an internationally recognized leader, is Austria's latest super-specialty center. Opening in 2019, it is one of Europe's most modern Centers. The hospital has a Heart and Vascular Center with a focus on aortic procedures and minimally invasive cardiovascular procedures and all techniques of CABG. The center performs approximately 500 CABG surgeries per year and is part of the ongoing DuraGraft EU Multicenter Registry to Assess Outcomes in CABG Patients: Treatment of Vascular Conduits with DuraGraft to Evaluate the Safety and Performance of DuraGraft (VASC). Based on the performance of DuraGraft in improving patient outcomes, the Cardiac Surgery Center at Vienna Heart Center North Floridsdorf in August 2020 recognized DuraGraft as the standard-of-care for CABG surgeries. 

"We have seen encouraging evidence that reinforces the importance of appropriate graft treatment during surgery and the role of DuraGraft in significantly improving outcomes in all patients. Additionally, we have observed significant myocardial protection utilizing DuraGraft during CABG, where we have implemented a recent study," said Associate Professor Priv. Doz. Dr. Bernhard Winkler at Vienna Heart Center North Floridsdorf.

The Chief of Cardiac Surgery at the hospital, Prof. Dr. Martin Grabwenwöger, said, "Saline, blood and buffered solutions have long been considered the standard-of-care for CABG surgery; however, studies have shown that DuraGraft outperforms its predecessors. We are thrilled to have DuraGraft as our new standard-of-care for graft treatments during CABG Surgery."

"The endothelial damage inhibitor, DuraGraft, has shown promising results in several preclinical studies and large-scale clinical investigations to adequately protect and preserve vascular conduits and in improving clinical outcomes. Therefore, its use as standard-of-care for vascular conduit storage and prevention of ischemic injury is not surprising," said Prof. Dr. Maximilian Emmert from the German Heart Center Berlin, Germany and PI of the VASC Registry.

Dr. Neil J. Campbell, Chief Executive Officer of Marizyme, stated, "Clinical evidence generated by independent researchers around the world have shown that DuraGraft improves CABG clinical outcomes resulting in DuraGraft providing a value proposition to patients, cardiac centers and healthcare systems worldwide. We at Marizyme are extremely excited to offer this product to CABG patients."

About CABG and DuraGraft
When patients with heart disease undergo CABG surgery, free vein or arterial grafts harvested from the leg, arm or chest are frequently used to bypass occluded coronary arteries; about 90% of CABG surgeries use at least one free vein graft. In most cases, in the time between harvesting and bypass grafting, the free graft is stored in saline or autologous blood which do not protect the graft from ischemic injury thereby increasing the risk of ischemia-reperfusion injury and graft disease and ultimate failure leading to post-CABG myocardial infarction and the need for repeat revascularization procedure.

DuraGraft is a CE-marked product that protects vascular grafts against ischemic injury and is the only product approved for graft protection and preservation during bypass and other vascular surgeries. DuraGraft protects graft tissue from harvesting through anastomosis and is used during vascular surgery (including CABG) as a treatment to maintain the structural and functional integrity of isolated vascular grafts. The use of DuraGraft is associated with the reduction of post-CABG complications associated with graft disease and failure: Myocardial Infarction, Repeat Revascularization, and MACE.

Clinical studies in more than 3,000 patients support the long-term safety and efficacy of DuraGraft. The use of DuraGraft in CABG surgery is associated with statistically significant lower risks for clinical complications following CABG; 45% reduction in non-fatal myocardial infarction (MI) (p <.0001), 35% reduction in repeat revascularization (p=0.037), and 19% reduction of MACE (a composite of all major adverse cardiac events) (p=0.005) (Haime et al. 2018).

About Vienna Heart Center North Floridsdorf
The latest super-specialty heart center, one of the most modern centers in Europe, 800 beds with a large unit together cardio-vascular, interventional radiology, cardiology.

About Marizyme, Inc.
Marizyme, Inc. is a development-stage company dedicated to the commercialization of therapies that address the urgent need relating to higher mortality and costs in the acute care space.  Specifically, Marizyme will focus its efforts on developing and acquiring treatments for those diseases. Through its recent acquisition of Somahlution it has acquired products and product candidates that reduce the burden of ischemia reperfusion injury in tissue grafting, organ transplant, and other surgical indications. The company's flagship product, DuraGraft, is a vascular graft treatment that improves clinical outcomes by reducing the incidence of complications associated with graft failure. DuraGraft enhances CABG surgical outcomes by significantly reducing major cardiac events such as repeat revascularization and myocardial infarction.  For more information about Marizyme, visit www.marizyme.com.

Forward-Looking Statements
This press release may contain certain forward-looking statements, including those relating to the Marizyme's product development, clinical and regulatory timelines, market opportunity, competitive position, possible or assumed future results of operations, business strategies, potential growth opportunities and other statements that are predictive in nature. The Company has made every reasonable effort to ensure the information and assumptions on which these statements are based are current, reasonable and complete. However, a variety of factors, many of which are beyond the Company's control, affect the Company's operations, performance, business strategy and results and there can be no assurances that the Company's actual results will not differ materially from those indicated herein. Additional written and oral forward-looking statements may be made by the Company from time to time. Forward-looking statements may be identified by the use of forward-looking  expressions, including, but not limited to, "expect," "anticipate," "intend," "plan," "believe," "estimate,"  "potential," "predict," "project," "should," "would" and similar expressions and the negatives of those  terms. These statements relate to future events or our financial performance and involve known and  unknown risks, including those risks set forth in the Company's risk factor disclosure in its Registration  Statement on Form 10K filed with the Securities and Exchange Commission (SEC File No. 000-53223),  uncertainties, and other factors which may cause actual results, performance or achievements to be  materially different from any future results, performance or achievements expressed or implied by the  forward-looking statements. Prospective investors are cautioned not to place undue reliance on such forward-looking statements, which speak only as of the date of this press release. The Company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise.

Contacts
Tiberend Strategic Advisors, Inc.
Investors
Maureen McEnroe, CFA/Miriam Miller
212-375-2664 / 212-375-2694
mmcenroe@tiberend.com
mmiller@tiberend.com

Media
Ingrid Mezo
646-604-5150
imezo@tiberend.com

Related Links

https://marizyme.com

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