Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

Kanazawa University Research: Discovery of a Molecule Facilitating Cancer Diagnosis


News provided by

Kanazawa University

05 Jun, 2019, 10:20 GMT

Share this article

Share toX

Share this article

Share toX

KANAZAWA, Japan, June 5, 2019 /PRNewswire/ -- Researchers at Kanazawa University report in Nature Chemical Biology the identification of a molecule capable of inhibiting cell growth in cancer microenvironment.  The discovery is relevant for diagnostic tumor imaging and could also contribute to the development of cancer treatment.

One of the processes involved in the progression of cancer is the activation of a molecule known as hepatocyte growth factor (HGF).  Normally, HGF is a passive molecule, occurring in blood and tissue; it consists of a single chain (scHGF) of polypeptides.  In a cancer microenvironment, however, a cleavage of scHGF happens, resulting in a two-chain structure (tcHGF), which makes the molecule active: tcHGF triggers a signaling pathway causing the growth of cells. Detecting active HGF is important for diagnosing and treating cancer. Now, an interdisciplinary team of researchers, including Kunio Matsumoto, Katsuya Sakai and Mikihiro Shibata at the WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Hiroaki Suga at the Department of Chemistry, Graduate School of Science, The University of Tokyo, Hidefumi Mukai and Yasuyoshi Watanabe at RIKEN Center for Biosystems Dynamics Research and colleagues have identified a molecule, called HiP-8, that can selectively recognize tcHGF. Moreover, HiP-8 binding to tcHGF hinders the latter's signaling activity, inhibiting the proliferation of cancer cells.

In trying to find candidate molecules that can inhibit active HGF, the researchers looked within the class of macrocyclic peptides — molecules nowadays extensively researched as candidates for drugs targeting protein–protein interactions involved in biochemical signaling pathways. Using the outstanding technology known as the 'RaPID system' that rapidly screens the diverse maclocyclic library (1012 – 1014 diversity), Matsumoto and colleagues arrived at a shortlist of 16 candidate 'HGF-inhibitory peptides' (HiPs) that they then synthesized and tested.

HiP-8 was found to have the best properties.  In in vitro experiments, HiP-8 potently inhibited the cellular response in tumor cells induced by HGF.  It was also successfully tested that HiP-8 does not inhibit other pathways — in other words, that the molecule only targets tcHGF. The scientists were able to describe the precise structural difference between sc- and tcHGF, and discovered that the inhibition by HiP-8 of the latter is allosteric (meaning that HiP-8 binds to tcHGF at a site that is not the active one). By using high-speed atomic force microscopy, they observed a movie for dynamic change of molecular shape, before and after HiP-8 binding to HGF. The molecular shape of HGF was dynamically changing, but it was suppressed after HiP-8 binding. A small molecule inhibits dynamic movement of a large molecule, like 'static inhibition'.

The researchers also investigated the effect of administering HiP-8 intravenously in a mouse model, to check its potential as a PET (positron-emission tomography) imaging probe. Good, non-invasive visualization of the mouse tumor was obtained in this way.

The work of Matsumoto and colleagues shows, with HiP-8 in the context of tcHGF as an example, the unique binding properties achievable with macrocyclic peptides. Quoting the researchers: "This [inhibiting] binding property of macrocyclic peptides and their advantages in imaging applications present considerable diagnostic and therapeutic development potential."

Background

Macrocyclic peptides

Macrocyclic peptides are molecules featuring peptides in a ring structure; a peptide is a biomolecule consisting of a chain of amino acids. Macrocyclic peptides form a large family of compounds and are found in many organisms, including bacteria, plants and mammals. Nowadays, the molecules are intensively researched as drug candidates because of suitable properties including synthetic accessibility and specific binding capabilities — especially binding to protein surfaces. Hiroaki Suga from University of Tokyo established the innovative technology known as the Random Peptide Integrative Discovery (RaPID) () system' which efficiently enables screening and discovery of macrocyclic peptides that bind to target protein. Kunio Matsumoto from Kanazawa University, Hiroaki Suga, and colleagues have now used RaPID screening to identify macrocyclic peptides capable of inhibiting the action of hepatocyte growth factor (HGF), a molecule involved in cancer progression. They found a series of HGF inhibitory peptides (HiPs), of which one, HiP-8, displays potent inhibition and can be used for the non-invasive visualization of tumors.

Positron-emission tomography

Positron-emission tomography (PET) is a technique used in nuclear medicine for visualizing biological processes in the body. The working principle is that of pairs of gamma rays being (indirectly) emitted by a so-called radioligand, which emits positrons (a positron is an electron-like, but positively charged, particle). The radioligand is attached to a biologically active molecule (called the radioactive tracer).  Matsumoto and colleagues applied PET with HiP-8 as the radioactive tracer, enabling the non-invasive visualization, and inhibition, of HGF.

Reference

Katsuya Sakai, Toby Passioura, Hiroki Sato, Kenichiro Ito, Hiroki Furuhashi, Masataka Umitsu, Junichi Takagi, Yukinari Kato, Hidefumi Mukai, Shota Warashina, Maki Zouda, Yasuyoshi Watanabe, Seiji Yano, Mikihiro Shibata, Hiroaki Suga, and Kunio Matsumoto. Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor, Nature Chemical Biology 15, 598−606 (2019).

DOI: 10.1038/s41589-019-0285-7

URL: https://doi.org/10.1038/s41589-019-0285-7

Positron-emission tomography (PET) images of mice bearing tumor, using HiP-8 as the radioactive tracer.

About Kanazawa University

As the leading comprehensive university on the Sea of Japan coast, Kanazawa University has contributed greatly to higher education and academic research in Japan since it was founded in 1949. The University has three colleges and 17 schools offering courses in subjects that include medicine, computer engineering, and humanities.

The University is located on the coast of the Sea of Japan in Kanazawa – a city rich in history and culture. The city of Kanazawa has a highly respected intellectual profile since the time of the fiefdom (1598-1867). Kanazawa University is divided into two main campuses: Kakuma and Takaramachi for its approximately 10,200 students including 600 from overseas.

Kanazawa University website: http://www.kanazawa-u.ac.jp/e/

Further information
Kanazawa University
Kakuma, Kanazawa, Ishikawa 920-1192, JAPAN
E-mail: intl.pr@adm.kanazawa-u.ac.jp
Tel: +81(76) 264-5963

Modal title

Also from this source

Kanazawa University research: From hydration layers to nanoarchitectures: Water's pivotal role in peptide organization on 2D nanomaterials

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, report in Small, a weekly peer-reviewed scientific journal...

Kanazawa University research: High-speed AFM and 3D modelling help towards understanding the dynamics of a protein implicated in several cancers

Researchers at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University observe and model how the enzyme ADAR1 interacts with...

More Releases From This Source

Explore

Education

Education

Health Care & Hospitals

Health Care & Hospitals

Medical Pharmaceuticals

Medical Pharmaceuticals

News Releases in Similar Topics

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • Accessibility Statement
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.