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Jazz Pharmaceuticals to Highlight Breadth of Research in Narcolepsy and Excessive Sleepiness in Obstructive Sleep Apnea at SLEEP 2018 Annual Meeting

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Jazz Pharmaceuticals plc

10 May, 2018, 12:30 GMT

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Twenty abstracts including eight oral presentations to showcase Jazz's breadth and depth of sleep medicine innovation 

DUBLIN, May 10, 2018 /PRNewswire/ -- Jazz Pharmaceuticals plc (Nasdaq: JAZZ) announced today that it will present 20 abstracts spanning the company's sleep portfolio at the 32nd Annual Meeting of the Associated Professional Sleep Societies, known as "SLEEP", in Baltimore from June 3-6, 2018.

"Jazz continues to invest in its pipeline and portfolio to deliver therapeutic options for the sleep community, and the breadth of data we are presenting at SLEEP is a testament to our substantial commitment to sleep medicine," said Jed Black, M.D., senior vice president, Sleep and CNS Medicine at Jazz Pharmaceuticals and adjunct professor, Stanford University Medical Center, Stanford Center for Sleep Sciences and Medicine. "We are particularly enthusiastic about our investigational medicine solriamfetol, which, if approved by the U.S. Food and Drug Administration, will offer patients a new and robust treatment option, and the first new chemical entity for the treatment of excessive sleepiness in narcolepsy and OSA in the U.S. in nearly 10 years."

On March 2, 2018, Jazz announced that the U.S. Food and Drug Administration (FDA) accepted for filing with standard review the company's New Drug Application (NDA) seeking marketing approval for solriamfetol (JZP-110), an investigational medicine for the treatment of excessive sleepiness in adult patients with narcolepsy or obstructive sleep apnea (OSA). 

Highlights at SLEEP will include:

  • Oral and poster presentations on results from an open-label, long-term safety and maintenance of efficacy study (TONES 5) of solriamfetol in the treatment of excessive sleepiness in patients with narcolepsy or OSA.
  • Oral and poster presentations examining the impact of solriamfetol on wakefulness throughout the day from the Phase 3 TONES 2 and TONES 3 studies.
  • Oral and poster presentations on post-hoc efficacy and safety analyses from the Phase 3 TONES 2 study for solriamfetol for excessive sleepiness in OSA, stratified by baseline cataplexy status.
  • Oral and poster presentations regarding the impact of narcolepsy and OSA on work productivity and quality of life.
  • Oral and poster presentations on the long-term safety and efficacy data from the Phase 2/3 study evaluating sodium oxybate in the treatment of pediatric patients with narcolepsy.
  • Poster on supporting safety for patients diagnosed with narcolepsy by restricting distribution of sodium oxybate to a central pharmacy using a central database and longitudinal monitoring.

A full list of Jazz-supported oral and poster presentations covering solriamfetol and sodium oxybate follows below:

Solriamfetol (JZP-110) Oral and Poster Presentations

Presentation Title

Author

Date / Time / Session/

Presentation Number/ Location

A Long-Term Safety and Maintenance of Efficacy Study of Solriamfetol (JZP-110) in the Treatment of Excessive Sleepiness in Subjects with Narcolepsy or Obstructive Sleep Apnea 

 

Malhotra  et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 331

 

June 5 1:30–2:30 p.m.

Oral Session O18

Abstract 620

 

Solriamfetol (JZP-110) in the Treatment of Excessive Sleepiness in Narcoleptic Patients With and Without Cataplexy: Results From a Randomized, Phase 3, Clinical Trial

 

Dauvilliers  et al.

 

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 332

 

June 5 1:30–2:30 p.m.

Oral Session O18

Abstract 619

 

Solriamfetol (JZP-110) in the Treatment of Excessive Sleepiness in Narcolepsy and Obstructive Sleep Apnea: Maintenance of Wakefulness Test Results Across the Day

 

Schweitzer et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 329

 

June 5 1:30–2:30 p.m.

Oral Session O18

Abstract 622

 

Measures of Function, Work Productivity, and Quality of Life From a Phase 3 Study of Solriamfetol (JZP-110) in Patients with Narcolepsy

 

Emsellem et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 330

 

June 5 1:30–2:30 p.m.

Oral Session O18

Abstract 621

 

Impacts of Excessive Sleepiness Associated With Obstructive Sleep Apnea on Work Productivity

 

Waldman et al.

June 3  5:00-7:00 p.m. 

Poster Session P02 

Poster 59

 

June 4 1:45–2:45 p.m.

Oral Session O09

Abstract 462

 

Using Multiple Anchor-based And Distribution-based Estimates To Determine The Minimal Important Difference (MID) For The FOSQ-10

 

Weaver  et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 343

 

June 4 3:00-5:00 p.m.

Oral Session O12

Abstract 612

 

US Healthcare Claims Analysis of Obstructive Sleep Apnea Comorbidities and Their Association with Stimulant Drug Use

 

Ohayon et al.

 

June 5  5:00-7:00 p.m. 

Poster Session P28 

Abstract 1085 Poster 140

 

Sodium oxybate / Narcolepsy-related Oral and Poster Presentations

Presentation Title

Author

Date / Time / Session/

Presentation Number/ Location

Sodium Oxybate Treatment of Pediatric Narcolepsy: Effects on Weight, Height, and Pubertal Development

Dauvillier et al.

June 4  5:00-7:00 p.m. 

Poster Session P13 

Abstract 0785 Poster 021

Sodium Oxybate Treatment of Narcolepsy in Pediatric Patients: Long-term Efficacy and Safety 

 

Mignot et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Poster 352

 

June 5 2:45–4:45 p.m.

Oral Session O20

Abstract 813

 

Pharmacokinetics of Sodium Oxybate in Children and Adolescents with Narcolepsy with Cataplexy

Rosen et al.

June 4  5:00-7:00 p.m. 

Poster Session P13 

Abstract 0837 Poster 019

 

Clinical and Patient Global Impression in a Phase 2/3 Study of Sodium Oxybate in Children and Adolescents with Narcolepsy with Cataplexy

Ruoff et al.

June 4  5:00-7:00 p.m. 

Poster Session P13 

Abstract 0838 Poster 020

 

Injuries, Motor Vehicle Accidents, and Near Misses in Narcolepsy: Results from the Nexus Narcolepsy Registry 

Ohayon  et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Abstract 0629 Poster 344

Disease Burden in Pediatric Narcolepsy: a Claims-based Analysis of Healthcare Utilization and Costs, and Medical Comorbidity

 

Reiss Reddy et al.

June 3  5:00-7:00 p.m. 

Poster Session P10 

Poster 297

 

June 5 2:45–4:45 p.m.

Oral Session O20

Abstract 812

 

Predictors of Time to Narcolepsy Diagnosis in Participants with Adult Onset of Symptoms: Results from the Nexus Narcolepsy Registry

Thorpy et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Abstract 0636 Poster 351

 

US Prevalence of Narcolepsy and Other Sleep Disorders From 2013-2016: a Retrospective, Epidemiological Study Utilizing Nationwide Claims

Hess et al.

June 3  5:00-7:00 p.m. 

Poster Session P12 

Abstract 0625 Poster 335

 

Supporting Safety for Patients Diagnosed with Narcolepsy by Restricting Distribution of Sodium Oxybate to a Central Pharmacy Using a Central Database and Longitudinal Monitoring

Strunc et al.

June 5  5:00-7:00 p.m. 

Poster Session P28

Abstract 1088 Poster 143

 

Additionally, the following investigator-sponsored trials focusing on sodium oxybate will be presented:

Defining Disrupted Nighttime Sleep in Pediatric Narcolepsy 

Maski et al.

June 4  5:00-7:00 p.m. 

Poster Session P13 

Abstract 0784 Poster 018

 

Role of diet in modulating the effects of sodium oxybate on weight gain in male Sprague-Dawley rats

Houser et al.

June 4  5:00-7:00 p.m. 

Poster Session P19

Abstract 0125 Poster 187

 

Diagnostic Accuracy and Validity of the Swiss Narcolepsy Scale for the Diagnosis of Type 1 and Type 2 Narcolepsy Against Other Central Disorders of Hypersomnolence

Bargiotas et al

June 3 5:00–7:00 p.m.

Poster Session P12

Abstract 0631  Poster 346 

The Bern Sleep-Wake Registry:

Calle et al

June 5 5:00–7:00 p.m.

Demographics And Clinical Characteristics of the First 6,831 Patients


Poster Session P38

Abstract 0733 Poster 334 

About Solriamfetol 
Solriamfetol (JZP-110) is a selective dopamine and norepinephrine reuptake inhibitor (DNRI) in development for treatment of excessive sleepiness in adult patients with narcolepsy, OSA, and Parkinson's disease. In 2014, Jazz Pharmaceuticals acquired a license to develop and commercialize solriamfetol from Aerial Biopharma. Jazz Pharmaceuticals has worldwide development, manufacturing, and commercialization rights to solriamfetol, excluding certain jurisdictions in Asia. SK Biopharmaceuticals, the discoverer of the compound (also known as SKL-N05), maintains rights in 12 Asian markets, including Korea, China and Japan. Solriamfetol has orphan drug designation in the United States for narcolepsy.  

About Xyrem 
Xyrem® (sodium oxybate) oral solution, CIII, is indicated for the treatment of cataplexy in narcolepsy and for the treatment of excessive daytime sleepiness in narcolepsy. Xyrem may only be dispensed to patients enrolled in the Xyrem REMS Program. Xyrem was first approved in the U.S. in 2002, based on clinical trial data in adults. The current United States Product Insert for Xyrem indicates that safety and effectiveness in pediatric patients have not been established. On April 27, 2018, Jazz submitted a supplemental NDA to FDA with revised proposed labeling to include data for use in pediatric patients, consistent with the FDA's pediatric written request.

IMPORTANT SAFETY INFORMATION 

Xyrem is a central nervous system (CNS) depressant. In clinical trials at recommended doses obtundation and clinically significant respiratory depression occurred in Xyremtreated patients. Almost all of the patients who received Xyrem during clinical trials in narcolepsy were receiving central nervous system stimulants.

Xyrem is the sodium salt of gamma hydroxybutyrate (GHB). Abuse of GHB, either alone or in combination with other CNS depressants, is associated with CNS adverse reactions, including seizure, respiratory depression, decreases in the level of consciousness, coma, and death.

Because of the risks of CNS depression, abuse, and misuse, Xyrem is available only through a restricted distribution program called the Xyrem REMS Program, using the central pharmacy that is specially certified. Prescribers and patients must enroll in the program. For further information go to www.XYREMREMS.com or call 1-866-XYREM88® (1-866- 997-3688).

Xyrem is contraindicated in combination with sedative hypnotics or alcohol and in patients with succinic semialdehyde dehydrogenase deficiency. 

Caution should be used when considering the concurrent use of Xyrem with other CNS depressants.  Healthcare providers should caution patients against hazardous activities requiring complete mental alertness or motor coordination within the first 6 hours of dosing or after first initiating treatment until certain that Xyrem does not affect them adversely. The rapid onset of sedation, coupled with the amnestic features of Xyrem, particularly when combined with alcohol, has proven to be dangerous for the voluntary and involuntary user (e.g. assault victim). Patients should be monitored for emergent or increased depression and suicidality and for impaired motor/cognitive function.  Episodes of sleepwalking should be fully evaluated and appropriate interventions considered.  The amount of daily sodium intake in each dose of Xyrem should be considered in patients sensitive to salt intake. The most common adverse reactions were nausea, dizziness, vomiting, somnolence, enuresis, and tremor.

Please click here to see the full Prescribing Information for Xyrem, including BOXED Warning.  

About the Nexus Narcolepsy Registry
The Nexus Narcolepsy Registry is an effort by Wake Up Narcolepsy and the narcolepsy research and advocacy communities, in collaboration with Jazz Pharmaceuticals, to collect deidentified data from a large group of people with narcolepsy over several years in order to shed light on the impact of the condition on people's lives. To learn more about the registry, please visit www.narcolepsyregistry.com.

About Jazz Pharmaceuticals plc
Jazz Pharmaceuticals plc (Nasdaq: JAZZ) is an international biopharmaceutical company focused on improving patients' lives by identifying, developing and commercializing meaningful products that address unmet medical needs. The company has a diverse portfolio of products and product candidates with a focus in the areas of sleep and hematology/oncology. In these areas, Jazz Pharmaceuticals markets Xyrem®(sodium oxybate) oral solution, Erwinaze® (asparaginase Erwinia chrysanthemi), Defitelio® (defibrotide sodium) and Vyxeos® (daunorubicin and cytarabine) liposome for injection in the U.S. and markets Erwinase® and Defitelio® (defibrotide) in countries outside the U.S. For country-specific product information, please visit www.jazzpharmaceuticals.com/products. For more information, please visit www.jazzpharmaceuticals.com and follow us on Twitter at @JazzPharma.

"Safe Harbor" Statement under the Private Securities Litigation Reform Act of 1995 This press release contains forward-looking statements, including, but not limited to, statements related to solriamfetol (JZP-110) as a potential treatment for excessive sleepiness in adult patients with narcolepsy or OSA and other statements that are not historical facts. These forward-looking statements are based on the company's current plans, objectives, estimates, expectations and intentions and inherently involve significant risks and uncertainties.  Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with: the regulatory approval process, including the risk that the company is unable to obtain FDA approval for solriamfetol in a timely manner or at all; and effectively commercializing solriamfetol; and other risks and uncertainties affecting the company and its development programs, including those described from time to time under the caption "Risk Factors" and elsewhere in Jazz Pharmaceuticals plc's Securities and Exchange Commission filings and reports (Commission File No. 001-33500), including the company's Quarterly Report on Form 10-Q for the quarter ended March 31, 2018 and future filings and reports by the company.  Other risks and uncertainties of which the company is not currently aware may also affect the company's forward-looking statements and may cause actual results and the timing of events to differ materially from those anticipated. The forward-looking statements herein are made only as of the date hereof or as of the dates indicated in the forward-looking statements, even if they are subsequently made available by the company on its website or otherwise. The company undertakes no obligation to update or supplement any forward-looking statements to reflect actual results, new information, future events, changes in its expectations or other circumstances that exist after the date as of which the forward-looking statements were made.

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