Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multichannel Amplification
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

iOnctura Announces Appointment of Leading International Scientific Advisory Board


News provided by

iOnctura SA

28 Nov, 2017, 09:33 GMT

Share this article

Share toX

Share this article

Share toX

GENEVA, November 28, 2017 /PRNewswire/ --

iOnctura SA, a recently founded late stage preclinical immuno-oncology company, announced today the formation of an international Scientific Advisory Board (SAB).

iOnctura is developing a pipeline of selected assets with novel biology that target and modulate mechanisms that drive immunosuppression in the tumour microenvironment (TME) to boost efficacy and maximize the therapeutic potential of checkpoint inhibitors. Such immune-suppression is thought to be one of the main reasons why a considerable number of patients do not respond to first generation checkpoint inhibitors. The company's lead program, a potentially first in class highly selective PI3K delta inhibitor, is scheduled to enter clinical development in 2018.

The Scientific Advisory Board will closely work with iOnctura's management team to maximise the potential of iOnctura's pipeline and rapidly progress its assets through pre-clinical and clinical proof of concept, guided by strong scientific rationale and translational science.

The SAB includes some of the world's leading experts in tumor immunology and checkpoint inhibitor therapy:

  • Dr Sergio A. Quezada, Head of Immune Regulation and Tumour Immunotherapy Research Group at University College London
  • Dr James Larkin, Consultant Medical Oncologist at The Royal Marsden, Vice Chair of the Cancer Research UK Clinical Research Committee and Lead of the Uncommon Cancers Theme at The Royal Marsden/The Institute of Cancer Research NIHR Biomedical Research Centre  
  • Professor Stuart Farrow, Director of Biology, Cancer Research UK's Therapeutic Discovery Laboratories.  
  • Dr Joern-Peter Halle, Head of External Innovation & Translational Innovation Platform Immuno-Oncology at the biopharma business of Merck KGaA, Darmstadt, Germany

iOnctura, has already built a pipeline of promising programs through its alliances with Merck KGaA, Darmstadt, Germany - which operates its biopharma business as EMD Serono in the US and Canada - and Cancer Research UK, and has entered into a research collaboration with Cancer Research UK's Therapeutic Discovery Laboratories.

On welcoming the members to the SAB, Catherine Pickering, CEO and co-founder of iOnctura, said: "We are delighted to have attracted this prestigious group of experts to our Scientific Advisory Board. Comprised of world renowned scientists and clinicians, their knowledge and experience in the field of cancer immunology will be invaluable as we rapidly progress our pipeline through pre-clinical development and clinical proof of concept, and will support our goal to maximize the therapeutic potential of checkpoint inhibitors for patients."

SCIENTIFIC ADVISORY BOARD  

Dr Sergio A. Quezada 

Dr Quezada earned an undergraduate degree in biochemistry from the P. Universidad Católica de Chile and a Ph.D. from Dartmouth Medical School in the US, where his research focused on the mechanisms for the induction of transplantation tolerance. Working with Prof Randy Noelle at Dartmouth, Dr. Quezada developed a model to study anti-CD154 graft tolerance and made several fundamental contributions to the understanding of the immune regulation and mechanisms of transplantation rejection and tolerance.

In 2004, Dr Quezada joined the laboratory of Dr James Allison at Memorial Sloan-Kettering Cancer Center, where he has carried out postdoctoral research aimed at understanding the mechanisms governing anti-tumor T-cell immunity and how these mechanisms can be manipulated for the generation of potent anti-tumor immune responses. In November 2011, Dr Quezada joined the University College London Cancer Institute in the United Kingdom as Head of the Immune Regulation and Tumor Immunotherapy group. His research group at UCL focuses in the study of the mechanism of action of anti-CTLA-4, anti-PD-1 and other immune-modulatory antibodies targeting co-inhibitory and co-stimulatory pathways (including ICOS, 4-1BB, OX-40) and used as novel anticancer therapies. In the last years, through a number of clinical collaborations, his team gained significant expertise in the characterisation and interrogation of immune reactivity and function within the microenvironment of different human cancers including melanoma, lung and kidney cancers.

Dr Quezada was a Cancer Research Institute Fellow from 2005 to 2008 and has been the recipient of Dartmouth's John W. Strohbern Medal for excellence in biomedical research, the Cancer Research Institute (USA) New Investigator Award and a Cancer Research UK Career Development Fellowship. Most recently he was awarded with a Cancer Research UK Senior Cancer Research Fellowship.

Dr James Larkin 

Dr James Larkin is a Consultant Medical Oncologist specialising in the treatment of melanoma and cancers of the kidney. Dr Larkin took a first in Natural Sciences from Cambridge University and undertook clinical training at Oxford University, qualifying in 1996. He underwent general medical training in London and in 2001 won a Medical Research Council Fellowship for a Clinician, carrying out laboratory research at The Institute of Cancer Research which led to the award of a PhD. He completed specialist training at The Royal Marsden and was appointed a Consultant in 2008.

His research interests involve trying to understand cancer and its consequences better as well as developing improved treatments, particularly with targeted therapies and immunotherapies. He is Chair of the Cancer Research UK Clinical Research Monitoring Panel, a medical advisor to the patient advocacy group Melanoma UK, a trustee of the Kidney Cancer Support Network and the only non-US member of the Board of Directors of the Kidney Cancer Association. He is a past NIHR National Specialty Lead for Early Phase Oncology Trials as well past Chair of both the NCRI Renal Cancer Clinical Studies Group and The Royal Marsden/ICR Committee for Clinical Research. He is currently Vice Chair of the Cancer Research UK Clinical Research Committee and Lead of the Uncommon Cancers Theme at the Royal Marsden/ICR Biomedical Research Centre for Cancer.

Professor Stuart Farrow 

Professor Stuart Farrow joined Cancer Research UK's Therapeutic Discovery Laboratories (then Cancer Research Technology Discovery Laboratories) as Director of Biology in April 2015, where he leads the discovery team responsible for oncology target validation and disease positioning. He has a particular focus on discovery of new therapeutic opportunities in immuno-oncology. Before joining Cancer Research UK's Therapeutic Discovery Laboratories he spent more than 20 years in drug discovery and leadership roles in the pharmaceutical industry. Most recently he was based at the University of Manchester, where he directed the establishment of the Manchester centre for collaborative research in inflammation and immunology (MCCIR), a £15M initiative funded by GSK, AstraZeneca and the University of Manchester. He has also served as a translational biology expert on the UK MRC Infection and Immunity Board. Stuart has worked in several therapeutic areas, leading discovery programmes from early discovery through to commercial launch, and has also directed major translational research initiatives. He has an extensive publication record with particular emphasis on immunology and inflammation.

Dr Joern-Peter Halle 

Dr Joern-Peter Halle is leading the External Innovation and Translational Innovation Platform Immuno-Oncology function at the biopharma business of Merck KGaA, Darmstadt, Germany. Most recently, he was Head of the President's Office and of Strategy and Business operations at the biopharma business of Merck KGaA, Darmstadt, Germany. Prior to this, he was responsible for the program leaders of the oncology portfolio, part of the cross-functional oncology leadership team, and Head of Early Stage Licensing of Merck KGaA, Darmstadt, Germany. He started his career in Merck KGaA, Darmstadt, Germany 12 years ago as a member of the corporate development team and was member of the Serono acquisition and integration team. Prior to joining Merck KGaA, Darmstadt, Germany, he co-founded a biotech company focusing on R&D in dermatology where he served as a Chief Business Officer. Peter holds a PhD in molecular biology from the University of Konstanz and began his career as a postdoc in biochemistry at the Gene Center Munich.

About iOnctura
iOnctura is a biopharmaceutical company focusing on novel therapeutics to modulate key culprits of immunosuppression in the tumor microenvironment. iOnctura aims to improve current immune checkpoint therapies by developing novel drugs with potential first or best-in-class safety and efficacy profiles that when combined with checkpoint inhibition have the potential to optimize clinical outcomes. Through its partnerships with Merck KGaA, Darmstadt, Germany and Cancer Research UK, iOnctura has established a pipeline of pre-clinical molecules to advance towards the clinic in combination with first generation checkpoint inhibitors. iOnctura, supported by a world renowned scientific advisory board and, with its access to Cancer Research UK's Therapeutic Discovery Laboratories and network of academic collaborators, is well-positioned to rapidly establish novel combination therapies in the field of cancer immunology. Headquartered in Geneva, Switzerland, iOnctura was founded by Merck Ventures, the strategic venture investment arm of Merck KGaA, Darmstadt, Germany in June 2017. Hakan Goker, Senior Investment Director at Merck Ventures, and Keno Gutierrez represent Merck Ventures on iOnctura's board of directors.

For more information contact:
Optimum Strategic Communications
Mary Clark, Supriya Mathur, Hollie Vile
Email: ionctura@optimumcomms.com
Tel: +44(0)203-714-1787

Modal title

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • Accessibility Statement
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.