Accessibility Statement Skip Navigation
  • Resources
  • Blog
  • Journalists
  • +44 (0)20 7454 5110
  • Client Login
  • Send a Release
Return to PR Newswire homepage
  • News
  • Products
  • Contact
When typing in this field, a list of search results will appear and be automatically updated as you type.

Searching for your content...

No results found. Please change your search terms and try again.
  • News in Focus
      • Browse News Releases

      • All Public Company News
      • All Multimedia News
      • View All News Releases

      • Regulatory News

      • D/A/CH Regulatory News
      • UK Regulatory News
      • View All Regulatory News

  • Business & Money
      • Auto & Transportation

      • Aerospace & Defense
      • Air Freight
      • Airlines & Aviation
      • Automotive
      • Maritime & Shipbuilding
      • Railroads & Intermodal Transportation
      • Supply Chain/Logistics
      • Transportation, Trucking & Railroad
      • Travel
      • Trucking & Road Transportation
      • View All Auto & Transportation

      • Business Technology

      • Blockchain
      • Broadcast Tech
      • Computer & Electronics
      • Computer Hardware
      • Computer Software
      • Data Analytics
      • Electronic Commerce
      • Electronic Components
      • Electronic Design Automation
      • Financial Technology
      • High Tech Security
      • Internet Technology
      • Nanotechnology
      • Networks
      • Peripherals
      • Semiconductors
      • View All Business Technology

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Financial Services & Investing

      • Accounting News & Issues
      • Acquisitions, Mergers & Takeovers
      • Banking & Financial Services
      • Bankruptcy
      • Bond & Stock Ratings
      • Conference Call Announcements
      • Contracts
      • Cryptocurrency
      • Dividends
      • Earnings
      • Earnings Forecasts & Projections
      • Financing Agreements
      • Insurance
      • Investments Opinions
      • Joint Ventures
      • Mutual Funds
      • Private Placement
      • Real Estate
      • Restructuring & Recapitalisation
      • Sales Reports
      • Shareholder Activism
      • Shareholder Meetings
      • Stock Offering
      • Stock Split
      • Venture Capital
      • View All Financial Services & Investing

      • General Business

      • Awards
      • Commercial Real Estate
      • Corporate Expansion
      • Earnings
      • Environmental, Social and Governance (ESG)
      • Human Resource & Workforce Management
      • Licensing
      • New Products & Services
      • Obituaries
      • Outsourcing Businesses
      • Overseas Real Estate (non-US)
      • Personnel Announcements
      • Real Estate Transactions
      • Residential Real Estate
      • Small Business Services
      • Socially Responsible Investing
      • Surveys, Polls & Research
      • Trade Show News
      • View All General Business

  • Science & Tech
      • Consumer Technology

      • Artificial Intelligence
      • Blockchain
      • Cloud Computing/Internet of Things
      • Computer Electronics
      • Computer Hardware
      • Computer Software
      • Consumer Electronics
      • Cryptocurrency
      • Data Analytics
      • Electronic Commerce
      • Electronic Gaming
      • Financial Technology
      • Mobile Entertainment
      • Multimedia & Internet
      • Peripherals
      • Social Media
      • STEM (Science, Tech, Engineering, Math)
      • Supply Chain/Logistics
      • Wireless Communications
      • View All Consumer Technology

      • Energy & Natural Resources

      • Alternative Energies
      • Chemical
      • Electrical Utilities
      • Gas
      • General Manufacturing
      • Mining
      • Mining & Metals
      • Oil & Energy
      • Oil & Gas Discoveries
      • Utilities
      • Water Utilities
      • View All Energy & Natural Resources

      • Environ­ment

      • Conservation & Recycling
      • Environmental Issues
      • Environmental Policy
      • Environmental Products & Services
      • Green Technology
      • Natural Disasters
      • View All Environ­ment

      • Heavy Industry & Manufacturing

      • Aerospace & Defence
      • Agriculture
      • Chemical
      • Construction & Building
      • General Manufacturing
      • HVAC (Heating, Ventilation & Air-Conditioning)
      • Machinery
      • Machine Tools, Metalworking & Metallurgy
      • Mining
      • Mining & Metals
      • Paper, Forest Products & Containers
      • Precious Metals
      • Textiles
      • Tobacco
      • View All Heavy Industry & Manufacturing

      • Telecomm­unications

      • Carriers & Services
      • Mobile Entertainment
      • Networks
      • Peripherals
      • Telecommunications Equipment
      • Telecommunications Industry
      • VoIP (Voice over Internet Protocol)
      • Wireless Communications
      • View All Telecomm­unications

  • Lifestyle & Health
      • Consumer Products & Retail

      • Animals & Pets
      • Beers, Wines & Spirits
      • Beverages
      • Bridal Services
      • Cannabis
      • Cosmetics & Personal Care
      • Fashion
      • Food & Beverages
      • Furniture & Furnishings
      • Home Improvement
      • Household, Consumer & Cosmetics
      • Household Products
      • Jewellery
      • Non-Alcoholic Beverages
      • Office Products
      • Organic Food
      • Product Recalls
      • Restaurants
      • Retail
      • Supermarkets
      • Toys
      • View All Consumer Products & Retail

      • Entertain­ment & Media

      • Advertising
      • Art
      • Books
      • Entertainment
      • Film & Motion Picture
      • Magazines
      • Music
      • Publishing & Information Services
      • Radio & Podcast
      • Television
      • View All Entertain­ment & Media

      • Health

      • Biometrics
      • Biotechnology
      • Clinical Trials & Medical Discoveries
      • Dentistry
      • FDA Approval
      • Fitness/Wellness
      • Health Care & Hospitals
      • Health Insurance
      • Infection Control
      • International Medical Approval
      • Medical Equipment
      • Medical Pharmaceuticals
      • Mental Health
      • Pharmaceuticals
      • Supplementary Medicine
      • View All Health

      • Sports

      • General Sports
      • Outdoors, Camping & Hiking
      • Sporting Events
      • Sports Equipment & Accessories
      • View All Sports

      • Travel

      • Amusement Parks & Tourist Attractions
      • Gambling & Casinos
      • Hotels & Resorts
      • Leisure & Tourism
      • Outdoors, Camping & Hiking
      • Passenger Aviation
      • Travel Industry
      • View All Travel

  • Policy & Public Interest
      • Policy & Public Interest

      • Animal Welfare
      • Corporate Social Responsibility
      • Economic News, Trends & Analysis
      • Education
      • Environmental
      • European Government
      • Labour & Union
      • Natural Disasters
      • Not For Profit
      • Public Safety
      • View All Policy & Public Interest

  • People & Culture
      • People & Culture

      • Aboriginal, First Nations & Native American
      • African American
      • Asian American
      • Children
      • Diversity, Equity & Inclusion
      • Hispanic
      • Lesbian, Gay & Bisexual
      • Men's Interest
      • People with Disabilities
      • Religion
      • Senior Citizens
      • Veterans
      • Women
      • View All People & Culture

  • Overview
  • Distribution
  • Paid Placement
  • Multimedia
  • Disclosure Services
  • SocialBoost
  • Rooms
    • MediaRoom
    • ESG Rooms
  • AI Tools
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Hamburger menu
  • Cision PR Newswire UK provides press release distribution, targeting, monitoring, and marketing services
  • Send a Release
    • Phone

    • +44 (0)20 7454 5110 from 8 AM - 5:30 PM GMT

    • ALL CONTACT INFO
    • Contact Us

      +44 (0)20 7454 5110
      from 8 AM - 5:30 PM GMT

  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • News in Focus
    • Browse News Releases
    • Regulatory News
  • Business & Money
    • Auto & Transportation
    • Business Technology
    • Entertain­ment & Media
    • Financial Services & Investing
    • General Business
  • Science & Tech
    • Consumer Technology
    • Energy & Natural Resources
    • Environ­ment
    • Heavy Industry & Manufacturing
    • Telecomm­unications
  • Lifestyle & Health
    • Consumer Products & Retail
    • Entertain­ment & Media
    • Health
    • Sports
    • Travel
  • Policy & Public Interest
    • Policy & Public Interest
  • People & Culture
    • People & Culture
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • Overview
  • Distribution
  • Paid Placement
  • Multimedia
  • Disclosure Services
  • Cision Communications Cloud®
  • AI Tools
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists
  • General Enquiries
  • Media Enquiries
  • Partnerships
  • Client Login
  • Send a Release
  • Resources
  • Blog
  • Journalists

HuidaGene Therapeutics Announces 19 Presentations Highlighting Advances in its Gene Therapy Technology Platforms at the 2023 ASGCT Annual Meeting

This image opens in the lightbox

News provided by

HuidaGene Therapeutics

03 May, 2023, 12:00 GMT

Share this article

Share toX

Share this article

Share toX

SHANGHAI and CLINTON, N.J., May 3, 2023 /PRNewswire/ -- HuidaGene Therapeutics (辉大基因; HuidaGene), a global clinical-stage genome-editing company focused on developing CRISPR-based programmable genomic medicine, today announced nineteen (19) presentations on Company's various gene replacement and gene-editing platforms to unlock the full potential of genome medicines at the upcoming American Society of Gene & Cell Therapy (ASGCT) Annual Meeting taking place in Los Angeles from May 16-20, 2023.

"This is the first time that HuidaGene has participated in ASGCT since the Company was founded 4 years ago. With the 100% acceptance rate for the 19 abstracts including 4 oral presentations, our presence at ASGCT showcases our leadership of technology advancement in gene replacement and genome-editing therapies to address their challenges and limitations. These presentations underscore our commitment to the unmet needs for patients and families living with devastating diseases around the world," said Xuan Yao, Ph.D., Co-Founder and Chief Executive Officer of HuidaGene.

"Based on our unique HG-PRECISE® platform, our team has developed various new genome editing tools (hfCas13X/Y, hfCas12Max, and eRBE etc), which not only have independent IP rights but also have advantages such as smaller size, higher editing efficiency and higher specificity. Therefore, our independently-developed genetic tools demonstrate improved editing efficiency and reduced off-target effects while making gene-editing therapy more effective, safer, and accessible to broader populations living with devastating diseases worldwide," stated Hui Yang, Ph.D., Co-Founder and Chief Scientific Advisor of HuidaGene. "I look forward to attending this international forum with my team to share the newest gene-editing advancement."

HuidaGene's presentations at 26th ASGCT Annual Meeting include:

Genetic Tools

Abstract #

Title

Date/Time

Format

Ophthalmology

Gene
replacement

713

Restoration of retinal function and structure in an RPE65- deficient murine model via. gene replacement therapy

5/17/2023 12:00-19:00

Poster

Cas12f

712

Compact CRISPR/Cas12f-based mutation independent therapy strategy for rhodopsin-associated autosomal dominant retinitis pigmentosa via single AAV

5/17/2023 12:00-19:00

Poster

Cas13

1663

Development of a Cas13-based RNA targeting therapy for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME)

5/19/2023 12:00-19:00

Poster

Gene
replacement

313

Preclinical safety assessment of an investigational gene replacement therapy for the treatment of RPE65-mediated inherited retinal dystrophies

5/20/2023 08:15-08:30

Petree Hall C

Oral

Neurology

Cas12i

694

Gene editing therapy in a humanized SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

5/17/2023 12:00-19:00

Poster

Cas13

34

RNA editing therapy in a humanized mouse model of MECP2 duplication syndrome and non-human primates

5/17/2023 16:15-16:30

Petree Hall D

Oral

Cas13

1624

A high-fidelity RNA-targeting Cas13 restores paternal Ube3a expression and improves motor functions in Angelman syndrome mice

5/19/2023 12:00-19:00

Poster

Cas12i

1285

Gene editing therapy in a humanized mouse model of Amyotrophic Lateral Sclerosis

5/19/2023 12:00-19:00

Poster

Otology

RNA base-
editor

342

Rescue of OTOF Q829X mutation-induced hearing loss by in-vivo delivery of mini-dCas13X-derived RNA base editor

5/20/2023 08:30-08:45

Room 502 AB

Oral

Myology

DNA base-
editor

667

Precise correction of Duchenne Muscular Dystrophy with exon 51 deletion by adenine base editing-induced exon skipping in a humanized mouse model

5/17/2023 12:00-19:00

Poster

RNA base-
editor

841

Efficient mini dCas13-mediated base editing for personalized treatment of Duchenne Muscular Dystrophy

5/18/2023 12:00-19:00

Poster

Cas12i

951

Single-cut gene editing therapy for Duchenne Muscular Dystrophy via a single AAV vector

5/18/2023 12:00-19:00

Poster

Hepatology

LNP-based
Cas12i

1128

Targeting the hepatitis B cccDNA with the hfCas12Max nuclease to eliminate hepatitis B virus in-vitro and in-vivo

5/18/2023 12:00-19:00

Poster

Technology

Cas12i

495

An engineered xCas12i with high activity, high specificity, and broad PAM range

5/17/2023 12:00-19:00

Poster

RNA base-
editor

978

Development of a compact and efficient RNA base editor (ceRBE) by fusing ADAR with engineered EcCas63

5/18/2023 12:00-19:00

Poster

Cas12f

1555

Engineering the novel type V-F CRISPR-Cas system as versatile and efficient genome editing tools delivered by a single AAV

5/19/2023 12:00-19:00

Poster

Cas13

1419

Engineered Cas13 with minimal collateral effect and improved editing efficiency for targeted RNA degradation

5/19/2023 12:00-19:00

Poster

AAV

1464

A comprehensive AAV tropism profile in mice, crab-eating macaques, and marmosets

5/19/2023 12:00-19:00

Poster

DNA base-
editor

257

Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase

5/19/2023 16:00-16:15

Concourse Hall 152&153

Oral

Accepted abstracts and full program is available at ASGCT website (https://annualmeeting.asgct.org/abstracts).

"This is the first time that HuidaGene has presented information on the progress of the scientific research in gene replacement and genome-editing therapies at the ASGCT annual meeting. Having 19 abstracts accepted for presentations with 4 oral presentations reflect the significant progress made by the teams and the strength of the R&D team's innovation and drug development in this field," commented by Alvin Luk, Ph.D, MBA, CCRA, Scientific Advisory Board Member of HuidaGene. "I'm very proud to be part of the groundbreaking work by the teams. I'll attend this ASGCT annual meeting with Prof. Yang and Dr. Yao. We're happy to have deep discussions with experts or companies wishing to advance gene therapy and gene editing technology. Together with Drs. Yang and Yao, we'll continue to advance the therapeutic pipeline and genome-editing research from discovery to bedside and bring more treatment options to patients globally."

About HuidaGene - 辉大基因

HuidaGene Therapeutics (辉大基因) is a global clinical-stage biotechnology company focusing on discovering, engineering, and developing CRISPR-based genetic medicine to rewrite the future of genomic medicine. Based in Shanghai and New Jersey, HuidaGene is committed to addressing patients' needs globally with various preclinical therapeutic programs covering ophthalmology, otology, myology, and neurology. We are currently advancing clinical programs in RPE65 mutation-associated inherited retinal dystrophies and our preclinical pipeline, including programs in neovascular age-related macular degeneration, retinitis pigmentosa, hereditary hearing loss, Duchenne muscular dystrophy, and MECP2 duplication syndrome. Company's CRISPR-based therapeutics offer the potential to cure patients with life-threatening conditions by repairing the cause of their disease. HuidaGene is committed to transforming the future of genome-editing medicine.

For more information, please visit http://www.HuidaGene.com  
or follow us on LinkedIn at http://www.linkedin.com/company/HuidaGene

Logo - https://mma.prnewswire.com/media/1990114/4017443/Huidagene_Logo.jpg

Modal title

Contact PR Newswire

  • +44 (0)20 7454 5110
    from 8 AM - 5:30 PM GMT
  • General Enquiries
  • Media Enquiries
  • Partnerships

Products

  • Content Distribution
  • Multimedia Services
  • Disclosure Services
  • Cision Communications Cloud®

About

  • About PR Newswire
  • About Cision
  • Partnering Opportunities
  • Careers
  • APAC
  • APAC - Simplified Chinese
  • APAC - Traditional Chinese
  • Brazil
  • Canada
  • Czech
  • Denmark
  • Finland
  • France
  • Germany
  • India
  • Indonesia
  • Israel
  • Japan
  • Korea
  • Mexico
  • Middle East
  • Middle East - Arabic
  • Netherlands
  • Norway
  • Poland
  • Portugal
  • Russia
  • Slovakia
  • Spain
  • Sweden
  • United States
  • Vietnam

My Services

  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
  • Data Privacy

Do not sell or share my personal information:

  • Submit via Privacy@cision.com 
  • Call Privacy toll-free: 877-297-8921

Contact PR Newswire

Products

About

My Services
  • All News Releases
  • Customer Portal
  • Resources
  • Blog
  • Journalists
+44 (0)20 7454 5110
from 8 AM - 5:30 PM GMT
  • Terms of Use
  • Privacy Policy
  • Information Security Policy
  • Site Map
  • RSS
  • Cookie Settings
Copyright © 2025 PR Newswire Europe Limited. All Rights Reserved. A Cision company.