DUBLIN, October 11, 2017 /PRNewswire/ --

The "3D Cell Cultures: Products, Technologies and Key Application Areas (2nd Edition), 2017-2030" report has been added to Research and Markets' offering.

The 3D Cell Cultures: Products, Technologies and Key Application Areas (2nd Edition), 2017-2030' report features an extensive study on the various scaffold-based and scaffold-free 3D culture systems.

We identified over 80 hydrogel / ECM based products, 70 inserts / plates / other cultureware and 50 3D bioreactors that are widely being used for a variety of research applications across the globe. In addition, several kits, assays and tools are also available to carry out cytotoxicity assessments, transfections and cell viability testing.

A number of research efforts in drug discovery are being directed towards the introduction of in vitro testing models that replicate the in vivo microenvironment and provide physiologically relevant insights. Cell culture monolayers or 2D cell cultures are known to harbor differences in morphology, growth rate, function, viability and the overall behavior, as compared to those in natural environment. However, it has been realized that 3D cell cultures facilitate cell interaction with the surrounding media in all the possible dimensions. Cells cultivated using 3D techniques provide an appropriate ecosystem for cells to grow and proliferate and, consequently generate more accurate results of the experiments conducted on them.

The 3D cell culture industry is currently characterized by presence of several scaffold-based and scaffold-free products and services, widely being used for the purpose of research across a variety of application areas. Examples of scaffold-based 3D culture products include solid scaffolds, hydrogels, ECM-coated plates and microcarriers. Products, such as hanging drop plates, ultra-low attachment surfaces, micropatterned plates and suspension culture systems (such as 3D bioreactors), are some of the important scaffold-free 3D technologies that are currently available.

It is worth highlighting that despite the advantages that they offer, the adoption of 3D cell cultures is hindered by certain challenges. These cell culture systems are currently limited to small scale production of cells, thereby, restricting their use to research applications only. Moreover, 3D culture techniques still need to be optimized in order to ensure consistency of results generated across different scales of operation. Due to the aforementioned challenges, 2D cultures continue to be preferred over 3D culture systems; however, with increasing awareness of the advantages of 3D cultures, a significant proportion of researchers are anticipated to gradually transition towards 3D culture systems.

It is well-known that, of the several drug / therapy candidates undergoing clinical evaluation, very few make it to advanced stages and an even lesser number receive regulatory approval. One of the key reasons for the failure of therapeutic candidates in clinical trials is the use of conventional 2D cell culture systems in early research studies. It is important to reiterate that these 2D systems are severely limited in a number of aspects.

Key Topics Covered:

1 PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines

2 EXECUTIVE SUMMARY

3 INTRODUCTION
3.1. Chapter Overview
3.2. Classification of Cell Cultures
3.3. Morphology of Cells in Culture
3.4. Transition from 2D to 3D Cell Culture
3.5. The Concept of 3D Cell Culture
3.6. Cell Cultures: Establishment and Maintenance
3.7. The Need for 3D Cell Culture Systems
3.8. Cell Culturing: Basic Requirements
3.9. 3D Cell Culture: Advantages and Limitations
3.10. Future Landscape of 3D Cell Culture

4 CLASSIFICATION OF 3D CELL CULTURE SYSTEMS
4.1 3D Cell Culture Classification: An Overview
4.2. Scaffold Based 3D Cell Cultures
4.3. Scaffold Free 3D Cell Cultures
4.4. Organoids

5 METHODS USED FOR FABRICATION OF 3D MATRICES AND SCAFFOLDS
5.1. Chapter Overview
5.2. Methods for Fabricating Porous Scaffolds
5.3. Methods for Fabricating Fibrous Scaffolds
5.4. Methods for Fabricating Hydrogels
5.5. Methods for Fabricating Custom Scaffolds
5.6. Methods for Fabricating Microspheres
5.7. Methods for Fabricating Native Scaffolds

6 MARKET OVERVIEW
6.1. Chapter Overview
6.2. 3D Cell Culture Products: List of Hydrogels/Extracellular Matrices (ECMs), Cultureware and Bioreactors
6.3. 3D Cell Culture Products: Assay Kits, Reagents and Services

7 3D CELL CULTURE: KEY APPLICATION AREAS
7.1. Chapter Overview
7.2. 3D Cell Culture Systems in Cancer Research
7.3. 3D Cell Culture Systems in Drug Discovery and Toxicity Screening
7.4. 3D Cell Culture Systems in Stem Cell Research
7.5. 3D Cell Culture Systems in Regenerative Medicine and Tissue Engineering
7.6. 3D Cell Culture Systems: Analyses on Key Application Areas

8 EMERGING TRENDS IN 3D CELL CULTURE ON SOCIAL MEDIA
8.1. Chapter Overview
8.2. 3D Cell Culture: Trends on Twitter

9 3D CELL CULTURE PRODUCTS: KEY PLAYERS
9.1. Chapter Overview
9.2. Developers of 3D Cultureware and ECMs/Hydrogels
9.2.1. 3D Biotek
9.2.2. Advanced BioMatrix
9.2.3. Alphabioregen
9.2.4. Corning Life Sciences
9.2.5. ReproCELL
9.3. Developers of Organs-on-Chips
9.3.1. CN Bio Innovations
9.3.2. Emulate
9.3.3. InSphero
9.3.4. MIMETAS
9.3.5. Nortis
9.3.6. TissUse

10 3D CULTURE BIOREACTORS: KEY PLAYERS
10.1. Chapter Overview
10.2.1 Celartia
10.2.2. Cell Culture Company
10.2.3. CESCO BioProducts
10.2.4. China Regenerative Medicine International
10.2.5. EBERS
10.2.6. PBS Biotech
10.2.7. Synthecon

11 MARKET FORECAST
11.1. Chapter Overview
11.2. Key Assumptions and Methodology
11.3. 3D Cell Culture Market Forecast, 2017-2030

12 SURVEY ANALYSIS
12.1. Chapter Overview
12.2. Overview of Respondents
12.3. Focus Area of the Company
12.4. Category of Lead Product(s)
12.5. Nature of Matrices
12.6. Development Status of Lead Product(s)
12.7. Sources of 3D Cultured Cells
12.8. Applications of 3D Cell Culture Products
12.9. Likely Market Size

13 CONCLUSION
13.1. 3D Cell Cultures, With Inherent Advantages over 2D Cell Cultures, are Gradually Gaining Attention in the Research Industry
13.2. Most 3D Cell Cultures Require a Supporting Scaffold for Growth and Propagation; However, Scaffold Free Techniques are Available as Well
13.3. Such Advanced Culture Systems have Found Use in a Myriad of Application Areas
13.4. Despite the Ongoing Innovation, 3D Cell Cultures are Yet to Unveil Potential in Mainstream Therapeutics
13.5. Post Mitigation of Associated Challenges, The Market is Likely to Witness a Higher Adoption
13.6. Overall, the 3D Cell Culture Market is Likely to Emerge as a Multi-Billion Dollar Market in the Long Term

14 INTERVIEW TRANSCRIPTS
14.1. Chapter Overview
14.2. Bill Anderson, President and Chief Executive Officer, Synthecon
14.3. Colin Sanctuary, Co-Founder and Chief Executive Officer, QGel
14.4. Darlene Thieken, Senior Management, Nanofiber Solutions
14.5. Jens Kelm, Chief Scientific Officer, InSphero
14.6. Scott Brush, VP Sales and Marketing, BRTI Life Sciences
14.7. Anonymous, President and Chief Executive Officer, Leading Company in 3D Cell Culture Domain
14.8. Anonymous, VP-Technical, Business Operations & Co-Founder, Leading Company in 3D Cell Culture Domain

15 APPENDIX: TABULATED DATA

16 APPENDIX: LIST OF COMPANIES AND ORGANIZATIONS

Companies Mentioned

• 101Bio
• 3D Biomatrix
• 3D Biotek
• 4titude
• AbbVie
• Accellta
• ACEA Biosciences
• Advanced BioMatrix
• AIM Biotech
• AK Biomedical
• Akron Biotech
• Alnylam Pharmaceuticals
• Alphabioregen
• AMS Biotechnology
• Antleron
• Applikon Biotechnology
• ARL Designs
• AstraZeneca
• AUCTEQ Biosystems
• AvantiCell Science
• AxoSim
• Bangalore Integrated System Solutions Tissue Growth Technologies (BiSS TGT)
• BASF
• BD Biosciences
• BellBrook Labs
• Benitec Biopharma
• Bio-Byblos Biomedical
• BioCellChallenge
• BioConnect
• Biogelx
• Biomaterials
• BioMedical Tissues
• Biomerix
• Biomimiq
• Biopta
• Biotronix
• Boston Institute of Biotechnology
• Bristol-Myers Squibb
• BRTI Life Sciences
• Celartia
• Celenys
• Cell Culture Company
• Cellec Biotek
• Cellendes
• Cellevate
• CellSpring
• CellSystems
• CelVivo
• CESCO BioProducts
• Cherry Biotech
• China Regenerative Medicine International
• China Stem Cell Clinical Applications Centre
• CN Bio Innovations
• Corning Life Sciences
• Cosmo Bio
• Covance
• Cyprotex
• CYTOO
• Dunn Labortechnik
• Durham University
• East River BioSolutions
• EBERS
• Ectica Technologies
• EMD Millipore
• Emulate
• EPISKIN
• Epithelix
• Eppendorf
• ESI BIO
• ETH Zurich
• Fennik Life Sciences
• FiberCell Systems
• Fraunhofer IGB
• Fraunhofer IWS
• FUJIFILM
• GE Healthcare
• GeneON
• GlaxoSmithKline
• Global Cell Solutions
• Greiner Bio-One
• HREL Corporation
• Hamilton Company
• HK International Regenerative Centre
• Hokkaido Soda
• Humeltis
• Imperial College London
• InSphero
• Instron
• InvitroCue
• InvivoSciences
• Iris Biosciences
• Japan Vilene
• Johnson & Johnson
• J-TEC
• KU Leuven
• Kirkstall
• KIYATEC
• Koken
• Kollodis BioSciences
• Kuraray
• LAMBDA Laboratory Instruments
• Leibniz Research Centre for Working Environment and Human Factors
• Lena Biosciences
• LFB Biomanufacturing
• Life Technologies
• Lifecore Biomedical
• Linari Engineering
• Locate Therapeutics
• Lonza
• LuoLabs
• Massachusetts Institute of Technology
• MatTek
• MBL International
• MD Biosciences
• Menicon Life Science
• Merck
• MicroTissues
• MIMETAS
• Mirus Bio
• MRC Centre for Drug Safety Science
• Nano3D Biosciences
• Nanofiber Solutions
• Nanogaia
• National Cancer Institute
• NC3Rs
• Neuromics
• Nortis
• Novadip
• ORGANOGENIX
• Organovo
• PBS Biotech
• PELOBiotech
• PepGel
• Percell Biolytica
• Pfizer
• Pishon Biomedical
• Pluristem Therapeutics
• ProBioGen
• Promega
• ProSys
• Protista
• QGel Bio
• Quinxell Technologies
• Radboudumc
• RealBio Technology
• RegeneMed
• Reinnervate
• ReproCELL
• Roche
• Sanofi
• Sarstedt
• Sartorius Stedim Biotech
• SCIVAX Life Sciences
• Seres Therapeutics
• Sigma-Aldrich
• SKE Research Equipment
• SkinAxis
• SoloHill Engineering
• SpheriTech
• StemCell Systems
• STEMCELL Technologies
• Stemmatters
• Stratatech
• StratiCELL
• Sumitomo Bakelite
• SUN Bioscience
• Synthecon
• SynVivo
• TAP Biosystems
• TARA Biosystems
• The Well Bioscience
• Thermo Fisher Scientific
• Tianjin Weikai Bioeng
• TissueClick
• TissUse
• Trevigen
• TU Berlin
• TU Dortmund
• UB-Care
• Univalor
• University College London
• University of Liverpool
• University of Oxford
• University of Pittsburgh
• University of Zaragoza
• University of Zurich
• University of Wrzburg
• UPM Biochemicals
• Utrecht University
• Viscofan BioEngineering
• Vivo Biosciences
• Wyss Institute at Harvard University

For more information about this report visit https://www.researchandmarkets.com/research/qstwsm/3d_cell_cultures

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