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Cardio3 BioSciences Partner and Exploitation Manager of a Eur 6.8 Million FP7 Research Grant for AMCARE Program


News provided by

Cardio3 BioSciences

03 Dec, 2013, 16:35 GMT

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MONT-SAINT-GUIBERT, Belgium, December 3, 2013 /PRNewswire/ --

Cardio3 BioSciences SA (C3BS) (NYSE Euronext Brussels and Paris: CARD), a leader in the discovery and development of regenerative, protective and reconstructive therapies for the treatment of cardiac diseases, and member of a research consortium under the
7th Framework Programme (FP7) of the European Commission's Research and Innovation today announces that it has obtained a second FP7 grant ; €6.8m for a project to develop restorative therapies for acute myocardial infarction.

The objective of this research program titled "Advanced Materials for Cardiac Regeneration" or AMCARE is to develop materials to regenerate cardiac tissue following heart attacks. It consists of developing and coupling natural materials and new minimally-invasive drug delivery systems to enhance the delivery of the body's own stem cells to the heart to promote healing after a heart attack (myocardial infarction).

Cardiovascular diseases are the number one cause of death globally, killing an estimated 17 million people each year. The European Society of Cardiology estimates that one in every six men and one in every seven women in Europe will die from a myocardial infarction.  The heart receives its own blood supply from the coronary arteries, and during a myocardial infarction a blockage in these arteries leads to decreased heart blood flow resulting in heart cell death due to prolonged lack of oxygen and nutrients. The multimodal therapies being developed in the AMCARE programme aim to modify the underlying pathology of the post-myocardial infarction disease state, specifically by replacing lost heart cells with functionally competent viable cells using stem cells derived from the patient's own bone marrow.

This first-in-class, pan-European consortium has been awarded a grant of €6.8 million. It is composed of ten partners with complementary profiles and skills from five European Countries, led by Dr Garry Duffy.

Cardio3 BioSciences is the exploitation manager of the consortium and as such is in charge of exploiting the outcome of this research project. Cardio3 is also in charge of the development of one advanced drug delivery system (C-CathGel).

Dr Christian Homsy, CEO of Cardio3 BioSciences comment: "We are proud to be part of the AMCARE Consortium which represents a major interdisciplinary effort between stem cell biologists, experts in advanced drug delivery, research scientists, clinicians and research-active companies working together to develop novel therapeutics to address the challenges of treating acute heart disease. Being chosen as the exploitation manager demonstrates the confidence and the recognition of our peers in the expertise we have built over the past years. This is also the second significant FP7 program for which Cardio3 BioSciences is a Partner and Exploitation Manager."

Dr Garry Duffy, Department of Anatomy and Tissue Engineering Research Group RCSI, Co-ordinator of the AMCARE consortium, commented on the research funding, "We are delighted to lead the AMCARE programme and to translate new collaborative research for the benefit of patients with heart disease.  Regenerative medicine and stem cell therapies have the potential to revolutionise the treatment of patients who have suffered a myocardial infarction, and through AMCARE we will develop new technologies to enhance stem cell therapies for these patients by increasing targeting and ease of delivery using advanced biomaterials. Coronary artery revascularisation therapies are effective at restoring blood flow to the heart following a myocardial infarction, however residual heart scarring may remain permanently. Elimination of myocardial scarring and restoration of full cardiac function post-MI using stem cell therapies could eliminate the cascade of events that lead to heart failure."

FP7 is the EU's main instrument for supporting innovative research in Europe, and has two main strategic objectives: to strengthen the scientific and technological base of European industry and to encourage its international competitiveness, while promoting research that supports EU policies.

The project is funded by the European Union's 'Seventh Framework' Programme (FP7/ http://cordis.europa.eu/fp7/home_en.html) under Grant Agreement n° NMP3-SME-2013-604531 from November 2013 to October 2018.

About Cardio3 BioSciences

Cardio3 BioSciences is a leading Belgian biotechnology company focused on the discovery and development of regenerative and protective therapies for the treatment of cardiac diseases. The company was founded in 2007. Cardio3 BioSciences leverages research collaborations in the US and in Europe with, amongst other, Mayo Clinic and the Cardiovascular Centre Aalst, Belgium.

The Company's lead product candidate C-Cure® is an innovative pharmaceutical product that is being developed for heart failure indication. C-Cure® consists of a patient's own cells that are harvested from the patient's bone marrow and engineered to become new cardiac progenitor cells that behave like those cells lost to heart disease. This reprogramming process is known as Cardiopoiesis.

Cardio3 BioSciences has also developed C-Cath®ez, a technologically advanced injection catheter with superior efficiency of delivery of biotherapeutic agents into the myocardium.  

Cardio3 BioSciences' shares are listed on NYSE Euronext Brussels and NYSE Euronext Paris under the ticker symbol CARD.

C3BS-CQR-1, C-Cure®, C-Cath, Cardio3 BioSciences and the Cardio3 BioSciences and C-Cath logos are trademarks or registered trademarks of Cardio3 BioSciences SA, in Belgium, other countries, or both. In addition to historical facts or statements of current condition, this press release contains forward-looking statements, which reflect our current expectations and projections about future events, and involve certain known and unknown risks, uncertainties and assumptions that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. These risks, uncertainties and assumptions could adversely affect the outcome and financial effects of the plans and events described herein. These forward-looking statements are further qualified by important factors, which could cause actual results to differ materially from those in the forward-looking statements, including timely submission and approval of anticipated regulatory filings; the successful initiation and completion of required Phase III studies; additional clinical results validating the use of adult autologous stem cells to treat heart failure; satisfaction of regulatory and other requirements; and actions of regulatory bodies and other governmental authorities.

Cardio3 BioSciences
Dr Christian Homsy, CEO/Patrick Jeanmart CFO
Anne Portzenheim, Communication Manager
http://www.c3bs.com
Tel : +32-10-39-41-00
aportzenheim@c3bs.com

Citigate Dewe Rogerson
Chris Gardner/David Dible
Tel : +44(0)207-638-9571
chris.gardner@citigatedr.co.uk

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