FN Media Group Presents USA News Group News Commentary
LOS ANGELES, June 25, 2020 /PRNewswire/ -- USA News Group – In a major step forward, engineers from MIT have designed nanoparticles that stimulate the immune system, helping it to attack tumors. This could contribute significantly to other immunotherapy approaches now under development.
Many biotech companies working in the field of treatment of cancer are developing new and novel therapies that could potentially benefit from this new approach including Roche Holding AG (OTCQX: RHHBY), Xynomic Pharmaceuticals Holdings, Inc. (OTCPK: XYNO) and Can-Fite Biopharma Ltd. (NYSE: CANF).
Immunotherapies are the latest vanguard in the battle against many forms of cancer. This promising strategy is designed to treat cancer by stimulating the body's own immune system to attack tumors. However, tumors are very good at suppressing the immune system and becoming invisible to the immune system, so these types of treatments don't work for all patients.
It is anticipated that the new therapies may transition to a lead cancer treatment in the near future. An emerging therapy discovery company on this path to providing solutions is Oncolytics Biotech Inc. (NASDAQ: ONCY) (TSX: ONC). Oncolytics is a development stage biotech company working on an immuno-oncology virus known as pelareorep. Pelareorep is a safe and well-tolerated drug that bolsters the power of T-cells fighting cancer.
The work across this entire research area is advancing at an incredible rate and attracting some of the best minds in the biotechnology field.
New Nanoparticles May Help Other Advances
The brain trust of MIT engineers has managed to come up with a way to boost the effectiveness of one type of cancer immunotherapy. The team working on the research say they showed that if they treated mice with existing drugs known as checkpoint inhibitors, along with new nanoparticles they have engineered that further stimulate the immune system, the therapy became more powerful than using the checkpoint inhibitors alone. Implementing a multifaceted treatment in this way could allow cancer immunotherapy to benefit a greater percentage of patients, the researchers say.
"These therapies work really well in a small portion of patients, and in other patients they don't work at all. It's not entirely understood at this point why that discrepancy exists," says Colin Buss PhD '20, the lead author of the new study.
Oncolytics Biotech A Contributor to the Field
The mechanics of Oncolytics Biotech's approach operate on this same premise that cancer grows in our bodies because our immune systems do not recognize these tumors as foreign or a threat. The cancer effectively "tells" our immune system and therefore T-cells, to allow the tumor cells to grow and increase, instead of attacking and destroying it. Immunotherapies – including checkpoint inhibitors – provide the means for our immune systems to recognize and then destroy the cancer. The challenge though is data which show that as low as 1 in 5 patients respond to checkpoint inhibitors, which are the largest and fastest growing segment of immunotherapies for cancer.
This is the battlefront for Oncolytics Biotech's pelareorep. The company's treatment has the potential to increase the percentage of patients who respond to checkpoint inhibitors. To prove out its concept, the treatment is being studied for potential combination with other treatments including Opdivo® from Bristol-Myers Squibb Company, Roche's Tecentriq®, Pfizer's and Merck's KGaA's Bavencio®, as well as Keytruda ® from Merck & Co. Inc.
The company is engaged in four ongoing studies now with Pfizer, Merck KGaA, Bristol-Myers Squibb, and Roche. Those studies involve checkpoint inhibitors, breast cancer, multiple myeloma, and pancreatic cancer.
In early progress, Oncolytics Biotech® recently presented clinical data supporting a predictive biomarker of Pelareorep response in breast cancer at the ESMO Breast Cancer Virtual Meeting. Important points of the AWARE-1 trial demonstrate pelareorep primes an adaptive immune response:
- Systemic delivery yields robust pelareorep replication selectively in tumor cells.
- Pelareorep administration increases CelTIL - known to be associated with positive clinical outcomes.
- Peripheral T cell clonality emerges as potential predictive and prognostic biomarker.
Combing Approaches Offers New Hope
After creating their nanoparticles, the researchers from MIT reported testing them in several different mouse models of cancer. In three separate approaches, they tested the oligonucleotide nanoparticles first on their own, then checkpoint inhibitors on their own, and finally the two treatments in combination. Using the two treatments together produced the best results, by far according to the team.
"When we combined the particles with the checkpoint inhibitor antibody, we saw a vastly improved response relative to either the particles alone or the checkpoint inhibitor alone," Buss says. "When we treat these mice with particles and the checkpoint inhibitor, we can stop their cancer from progressing."
While there remains no single path or magic bullet to treating cancers using this new approach, the indications have heralded many new opportunities to create effective treatments for some common forms of cancer. Other companies are preparing to build on new and similar technologies, or potentially combine their treatments when possible. Leading companies capable of adding to the developing body of research and treatments include:
Roche Holding AG engages in the diagnostics and prescription pharmaceuticals businesses in Switzerland, Germany, and internationally. Roche Holding AG has announced that Tecentriq in combination with chemotherapy (including Abraxane) meets primary endpoint of improved pathological complete response, regardless of PD-L1 status, as initial treatment for people with early triple-negative breast cancer.
Xynomic Pharmaceuticals Holdings, Inc. is a clinical stage oncology-focused biopharmaceutical company. Its latest report announced the dosing of the first Chinese patient in its on-going global pivotal Phase 3 trial of Xynomic's abexinostat combined with pazopanib as a first- or second-line therapy against renal cell carcinoma (RCC) at Peking University Cancer Hospital & Institute. Dr. Jun Guo, Professor and Medical Director at Peking University Cancer Hospital & Institute, is the leading principal investigator for this trial in China.
Can-Fite BioPharma Ltd. (NYSE American: CANF) is an advanced clinical stage drug development Company with a platform technology that is designed to address multibillion-dollar markets in the treatment of cancer, inflammatory disease and sexual dysfunction. Can-Fite has announced that the company has successfully concluded a meeting with the Scientific Advice Working Party (SAWP) of the European Medicines Agency (EMA) regarding Phase III development of its drug candidate Namodenoson in the treatment of hepatocellular carcinoma (HCC), the most common form of liver cancer.
For more about developing new treatments and companies with advances, see the USA News Group article at https://usanewsgroup.com/2020/02/24/why-biotechnology-companies-are-so-important/
Nothing in this publication should be considered as personalized financial advice. We are not licensed under securities laws to address your particular financial situation. No communication by our employees to you should be deemed as personalized financial advice. Please consult a licensed financial advisor before making any investment decision. This is a paid advertisement and is neither an offer nor recommendation to buy or sell any security. We hold no investment licenses and are thus neither licensed nor qualified to provide investment advice. The content in this report or email is not provided to any individual with a view toward their individual circumstances. USA News Group is a wholly-owned subsidiary of Market IQ Media Group, Inc. ("MIQ"). MIQ has been paid a fee for Oncolytics Biotech Inc. advertising and digital media from the company directly. There may be 3rd parties who may have shares of Oncolytics Biotech Inc., and may liquidate their shares which could have a negative effect on the price of the stock. This compensation constitutes a conflict of interest as to our ability to remain objective in our communication regarding the profiled company. Because of this conflict, individuals are strongly encouraged to not use this publication as the basis for any investment decision. The owner/operator of MIQ own shares of Oncolytics Biotech Inc. which were purchased in the open market, and reserve the right to buy and sell, and will buy and sell shares of Oncolytics Biotech Inc. at any time without any further notice. We also expect further compensation as an ongoing digital media effort to increase visibility for the company, no further notice will be given, but let this disclaimer serve as notice that all material disseminated by MIQ has been approved by the above mentioned company; this is a paid advertisement, we currently own shares of Oncolytics Biotech Inc. and will buy and sell shares of the company in the open market, or through private placements, and/or other investment vehicles.
While all information is believed to be reliable, it is not guaranteed by us to be accurate. Individuals should assume that all information contained in our newsletter is not trustworthy unless verified by their own independent research. Also, because events and circumstances frequently do not occur as expected, there will likely be differences between the any predictions and actual results. Always consult a licensed investment professional before making any investment decision. Be extremely careful, investing in securities carries a high degree of risk; you may likely lose some or all of the investment.
DISCLAIMER: USA News Group is Source of all content listed above. FN Media Group, LLC (FNM), is a third party publisher and news dissemination service provider, which disseminates electronic information through multiple online media channels. FNM is NOT affiliated in any manner with USA News Group or any company mentioned herein. The commentary, views and opinions expressed in this release by USA News Group are solely those of USA News Group and are not shared by and do not reflect in any manner the views or opinions of FNM. FNM is not liable for any investment decisions by its readers or subscribers. FNM and its affiliated companies are a news dissemination and financial marketing solutions provider and are NOT a registered broker/dealer/analyst/adviser, holds no investment licenses and may NOT sell, offer to sell or offer to buy any security. FNM was not compensated by any public company mentioned herein to disseminate this press release.
This release contains "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E the Securities Exchange Act of 1934, as amended and such forward-looking statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. "Forward-looking statements" describe future expectations, plans, results, or strategies and are generally preceded by words such as "may", "future", "plan" or "planned", "will" or "should", "expected," "anticipates", "draft", "eventually" or "projected". You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause future circumstances, events, or results to differ materially from those projected in the forward-looking statements, including the risks that actual results may differ materially from those projected in the forward-looking statements as a result of various factors, and other risks identified in a company's annual report on Form 10-K or 10-KSB and other filings made by such company with the Securities and Exchange Commission. You should consider these factors in evaluating the forward-looking statements included herein, and not place undue reliance on such statements. The forward-looking statements in this release are made as of the date hereof and FNM undertakes no obligation to update such statements.
Media Contact Information:
FN Media Group, LLC
Media Contact e-mail:
U.S. Phone: +1(954)345-0611
SOURCE USA News Group