Proof of Concept Study Initial Findings
PERTH, Australia, Jan. 29, 2013 /PRNewswire/ -- Bone Medical Ltd (ASX: BNE), a biopharmaceutical company focused on the development of new medicines for musculoskeletal diseases, today announced initial findings from a proof of concept study of BN006, a treatment that it is developing for Rheumatoid Arthritis (RA) based on its Mozaic™peptide discovery technology.
These first results confirm that BN006 reduces inflammation in a collagen-antibody induced arthritis disease model, a widely used benchmark for evaluating and comparing novel treatments for RA. The reduction appeared to be dose-related.
Significantly, BN006 achieved notable reduction in inflammation with only a modest reduction of TNF. TNF is one of the body's inflammatory agents that play an important role in the RA disease process. BN006 has also been shown to reduce IL-6, another cytokine involved in RA.
Dr Roger New, CSO and inventor of the Mozaic™ system, explained, "The current standard of care for the treatment of RA works by binding to TNF and blocking its activity systemically. This approach reduces TNF's ability to play its role in the body's immune response, leading to the adverse events that most commonly limit the clinical role of these products."
"In our study, BN006 achieved its effect with only a small reduction in TNF," continued Dr New. "While adalimumab (Humira™) eliminated inflammation in our study, it almost completely blocked TNF. This provides experimental evidence for BN006's selective mechanism of action, which acts directly on macrophages to reduce their inflammatory activity, and confirms its potential to become an important advance in the treatment for RA."
Dr New said the Company was continuing to evaluate the results of the study, and would add another BN006 treatment arm to further expand the study outcomes. More complete results are expected over the next couple of months.
Dr Roger New
or visit: www.bone-ltd.com
About Bone Medical Limited
Bone Medical Limited focuses on developing significant new products for the treatment of bone diseases like osteoarthritis, rheumatoid arthritis, and osteoporosis. The Company's product pipeline includes Phase II clinical-stage programs for the oral delivery of CaPTHymone™ (parathyroid hormone) for osteoporosis and Capsitonin™ (calcitonin) for osteoarthritis pain and osteoporosis, and novel preclinical-stage compounds like BN006, BN007, a collagen tolerance & joint protection agent for RA, and BN005 & BN008, bone cell regulators for osteoporosis.
SOURCE Bone Medical Ltd
Journalists and Bloggers
Visit PR Newswire for Journalists for releases, photos and customised feeds just for Media.
View and download archived video content distributed by MultiVu on The Digital Center.
Until you hear the full story, why would you invest?
Making sound investment decisions can be difficult. You can study the figures and read the analyst recommendations, but how do you really know the story behind company strategy? How can you get answers to your questions?
The Private Investor Network helps you to reach an informed decision on the stocks you pick. Interactive presentations from UK listed companies give you the kind of access previously enjoyed only by the big fund managers. And with keynote speeches from industry experts, downloadable content and an investor lounge where you can swap tips with your peers, you can invest with confidence.
For more information, and to register for FREE, visit us at www.privateinvestornetwork.co.uk
Get content for your website
Enhance your website's or blog's content with PR Newswire's customised real-time news feeds.
Contact PR Newswire
Send us an email at MarketingUK@prnewswire.co.uk or call us at +44 (0)20 7454 5382
Become a PR Newswire client
Request more information about PR Newswire products & services or call us at +44 (0)20 7454 5382